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Expression of genes encoding extracellular matrix macromolecules and metallopro...
Velada, I; Capela e Silva, F; Reis, F; Pires, E; Egas, C; Rodrigues-Santos, P; Barros, MTAvian tibial dyschondroplasia (TD) is a skeletal disease characterized by disruption of endochondral bone formation. The aim of this study was to determine the expression of extracellular matrix (ECM) macromolecules and ECM-degrading enzymes [matrix metalloproteinases (MMPs)] in the growth plates of normal and TD-affected 3-week-old broiler chicks (Cobb strain). Protein levels were analyzed by immunoblotting an...
Monoclonal anti-CD8 therapy induces disease amelioration in the K/BxN mouse mod...
Raposo, BR; Rodrigues-Santos, P; Carvalheiro, H; Água-Doce, AM; Carvalho, L; Pereira da Silva, JA; Graça, L; Souto-Carneiro, MMOBJECTIVE: CD8+ T cells are part of the T cell pool infiltrating the synovium in rheumatoid arthritis (RA). However, their role in the pathogenesis of RA has not been fully delineated. Using the K/BxN mouse model of spontaneous chronic arthritis, which shares many similarities with RA, we studied the potential of CD8+ T cell depletion with monoclonal antibodies (mAb) to stop and reverse the progression of exper...
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