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Key role of AMPK in glucose-evoked Na,K-ATPase modulation
Rodrigues Costa, Ana; Capela e Silva, Fernando; Antunes, Célia; Cruz-Morais, JúlioBackground and aims: Na,K-ATPase is an integral membrane protein responsible for generating and maintaining transmembrane ionic gradients. It has been demonstrated that, in pancreatic β-cells, Na,K-ATPase is regulated by glucose and that this phenomenon is impaired in glucose intolerant subjects. However, the mechanism underlying glucose-induced modulation of Na,K-ATPase is still unclear. The AMP-activated prot...
Abnormal regulation of pancreatic beta cell Na,K-ATPase on glucose intolerant rats
Rodrigues Costa, Ana; Antunes, Celia M; Cruz-Morais, JúlioBackground and aims: Glucose (G) is the most important physiological insulin secretagogue. It is widely accepted that, in pancreatic -cell, G evoked early ionic events such as membrane depolarization and Ca2+ influx through voltage dependent Ca2+ channels triggers insulin exocytosis. However, the role of other electrogenic systems, namely ionic pumps, to these events remains essentially uninvestigated. It is k...
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