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Novel mitochondrial electron transport-chain inhibitors as potencial antimalari...

Tese de doutoramento, Farmácia (Química Farmacêutica e Terapêutica), Universidade de Lisboa, Faculdade de Farmácia, 2010 ; The bc1 complex is an attractive a validated drug target in the fight against malaria. The mitochondrial electron transport-chain, in which this complex is involved, is fundamental in Plasmodium sp.. The parasites do not possess the requested enzymatic machinery to salvage pyrimidines from...