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Sickle cell disease in children: chronic complications and search of predictive...

BACKGROUND: Sickle cell disease (SCD) has extremely variable phenotypes, and several factors have been associated with the severity of the disease. OBJECTIVES: To analyze the chronic complications of SCD and look for predictive risk factors for increased severity and number of complications. METHODS: Retrospective study including all children followed for SCD in the Paediatric Haematology Unit of a tertiary hos...

Uso de medicamentos em gestantes

Antecedentes/Objetivos: O uso de medicamentos por gestantes deve ser considerado um problema de saúde pública (Carmo, 2003; Baldon et al, 2006). É um comportamento de alto risco terapêutico com elevados riscos potenciais, sobretudo, para o feto, mas também para a gestante (Olesen et al, 1999; Oliveira & Fonseca, 2006). Os efeitos sobre o feto dependem do fármaco ou substância, da paciente, da época de exposição...

Validation of food photographs used to estimate food portion size across Pilot-...

Computerized dietary interviews: defining guidelines for the contruction of foo...

Harmonization of dietary quantification methods: can quantification common base...

Determinação do habitat potencial de Asphodelus bento-rainhae P. Silva com recu...

Asphodelus bento-rainhae P. Silva é uma espécie de Liliaceae, endémica da serra da Gardunha (Fundão). A sua área de distribuição ocupa cerca de 700 ha, exclusivamente na vertente norte, entre 530 a 810 m de altitude, em solos profundos resultantes de depósitos de vertente de corneanas e xistos mosqueados derivados de metaformismo de contacto dos xisto-grauvaque, repartindo-se por sete freguesias do concelho do ...

Determinação do habitat potencial de Asphodelus bento-rainhae P. Silva com recu...

Asphodelus bento-rainhae P. Silva é uma espécie de Liliaceae, endémica da serra da Gardunha (Fundão). A sua área de distribuição ocupa cerca de 700 ha, exclusivamente na vertente norte, entre 530 a 810 m de altitude, em solos profundos resultantes de depósitos de vertente de corneanas e xistos mosqueados derivados de metaformismo de contacto dos xisto-grauvaque, repartindo-se por sete freguesias do concelho do ...

Human plasma derived prothrombin complex concentrate (OCTAPLEX), the HFF, EPE:...

Background: The HPDPCC was introduced in our clinical practice in 2005, and it has some specific clinical recommendations . We use Octaplex mostly to recert coagulation parameters in patients whose status require their quick conversion, mainly to reverse oral anticoagulation. We initially started using Octaplex in lower doses than the recommended by the drug leaflet, trying to find an optimal dose, aiming to av...

Prevalence of HLA antibodies in post pregnancies female blood donors

Background: Transfusion related acute lung injury (TRALI) is known as transfusion hazard with high morbidity and mortality rate. Mainly HLA class II have been associated with TRALI. Preventive measures are in the exclusion of donor female as they carry any these antibodies. Aim: We study a group of female blood donor with prior history of two or more pregnancies (G2), one (G1) pregnancy and without any pregn...

Transfusion therapy and sickle cell disease

Background: Sickle cell disease is a very common hemoglobinopathy. The main goal of transfusion therapy in sickle cell disease is to prevent thrombotic events, improve tissue oxygenation and treat anaemia complications. However the risk of all immunization is well known. Since 2001 our service has been doing a tight surveillance work in sickle cell patients, creating a database of about 15,000 studied blood d...