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The use of mice as animal model for testing acute toxicity (LD-50) of toxic sho...
Dias,R.S.; Carmo,L.S.; Heneine,L.G.D.; Rocha,P.H.; Barbosa,C.F.; Rodrigues,R.J.; Linardi,V.R.Acute toxicity test (LD-50) using toxic shock syndrome toxin (TSST-1) was tested in BALB/c, C57BL/6 and Swiss mice. Animals (n = 10) were intraperitoneally injected with TSST-1 (0.01-10.0µg/mouse) followed 4h later by potentiating dose of lipopolysaccharide (75.0µg of LPS - E. coli O111:B4) and cumulative mortality was recorded over 72h. Control animals received either TSST-1 or LPS alone. The data were submitt...
Anandamide and NADA bi-directionally modulate presynaptic Ca<sup>2+</sup> level...
Köfalvi, A.; Pereira, M. F.; Rebola, N.; Rodrigues, R. J.; Oliveira, C. R.; Cunha, R. A.Inhibitory CB1 cannabinoid receptors and excitatory TRPV1 vanilloid receptors are abundant in the hippocampus. We tested if two known hybrid endocannabinoid/endovanilloid substances, N-arachidonoyl-dopamine (NADA) and anandamide (AEA), presynapticaly increased or decreased intracellular calcium level ([Ca2+]i) and GABA and glutamate release in the hippocampus. Resting and K+-evoked levels of [Ca2+]i and the rel...
Purinergic P2 receptors trigger adenosine release leading to adenosine A2A rece...
Almeida, T.; Rodrigues, R. J.; Mendonça, A. de; Ribeiro, J. A.; Cunha, R. A.Electrophysiological recordings were used to investigate the effects of ATP analogues on [theta]-burst-induced long-term potentiation (LTP) in rat hippocampal slices. [alpha],[beta]-Methylene ATP ([alpha],[beta]-MeATP; 20 [mu]M) decreased LTP from 36±9% to 17±5%, an effect prevented by adenosine A1 receptor blockade in accordance with the localised catabolism of ATP analogues into adenosine, leading to adenosin...
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