Lung development is a methodical and coordinated process that culminates in the creation of an organ that contains airways, alveoli, blood vessels, multiple innate and acquired host defense systems, and processes to weaken the harmful effects of oxygen in the environment. By regulating cellular differentiation and branching morphogenesis, vitamin A plays an essential role during lung development. Retinoic acid ...
AIM: Ketamine can induce hepatotoxicity which has been suggested to be dependent on mitochondrial impairment. This study investigated the long-term effects of chronic low-dose ketamine on liver mitochondrial function, oxidative stress parameters, liver histology and glycogen content. MAIN METHODS: Adult rats were administered with saline or ketamine (5 or 10mg/kg) twice a day for a fourteen-day period in orde...
This study showed that a single intraperitoneal injection of ketamine did not induced necrosis or apoptosis in liver of adult mice. ; Portuguese Foundation for Science and Technology (Lisbon, Portugal) and co-funded by the COMPETE: -01-0124- FEDER -009497
O principal objetivo desta dissertação é aprofundar o conhecimento do romance Cerromaior, da autoria de Manuel da Fonseca, perceber a sua importância e significado no contexto histórico-literário do neorrealismo português, assim como evidenciar que o referido romance se enquadra nas características do subgénero literário romance de formação. Demonstra-se que, para além de se tratar de um romance que se enquadra...
CONTEXT: Ketamine is an anaesthetic and analgesic drug used in research and clinical practice. Little is known about the effects of different doses of this drug on memory and brain cellular death. OBJECTIVE: To study the effects of different doses of ketamine on working and reference memory, and neurodegeneration in adult mice. DESIGN: A randomised study. SETTINGS: The study was carried out in a basic scien...
Esta investigação tem como objetivo primordial analisar como os professores exploram e utilizam vários recursos didáticos em circunstância de aprendizagem, nas áreas da Educação Artística, especificamente no contexto de docência da disciplina de Educação Visual e Educação Tecnológica. O nosso enquadramento teórico aborda as competências essenciais, solicitadas na área de educação artística, o conceito de recurs...
Almonds (Prunus dulcis (Miller) D.A. Webb) and European (sweet) chestnuts (Castanea sativa Miller) are of great economic and social impact in Mediterranean countries, and in some areas they constitute the main income of rural populations. Despite all efforts to control fungal contamination, toxigenic fungi are ubiquitous in nature and occur regularly in worldwide food supplies, and these nuts are no exception. ...
Mestrado em Engenharia do Ambiente - Instituto Superior de Agronomia ; There is a growing awareness about environmental impacts associated with the use of large amounts of inorganic fertilizers, not only in Portugal, but worldwide. Plants require available nutrients to meet their metabolic needs, so that they can grow appropriately and sustain an increasing global population. Soil microorganisms play fundament...
Almonds (Prunus dulcis (Miller) D.A. Webb) and European (sweet) chestnuts (Castanea sativa Miller) are of great economic and social impact in Mediterranean countries, and some areas they constitute the main income of rural populations. Despite all efforts to control fungal contamination, toxigenic fungi are ubiquitous in nature and occur regularly in worldwide food supplies, and these nuts are no exception. Th...
Due to the high toxicity of mycotoxins, many methods have been used to reduce or eliminate them from food and feed. Gamma radiation is one technique that has been investigated with some promising results in degradation of some mycotoxins from food. The aim of this study was to clarify the effect of gamma irradiation on aflatoxin B1 (AFB1) aflatoxin B2 (AFB2), aflatoxin G1 (AFG1) and aflatoxin G2 (AFG2), ochatox...
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