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Preparation, characterization, bioactive and metal uptake studies of alginate/p...
Jayakumar, R.; Rajkumar, M.; Freitas, H.; Selvamurugan, N.; Nair, S.V.; Furuike, T.; Tamura, H.http://www.sciencedirect.com/science/article/B6T7J-4TVJNKT-1/2/4f8d5256058d114950f0b90cf6b4af87
Synthesis and characterization of N-methylenephenyl phosphonic chitosan
Jayakumar, R.; Reis, R. L.; Mano, J. F.Chitosan is a natural based polymer obtained by alkaline deacetylation of chitin, exhibiting excellent properties such as non‐toxicity, biocompatibility and biodegradability. N‐Methylenephenyl phosphonic chitosan (NMPPC) is synthesized from chitosan by reacting with phenyl phosphonic acid using formaldehyde. The NMPPC was characterized by FTIR, 31P‐NMR, X‐ray diffraction, scanning electron microscopy, thermogra...
Synthesis and characterization of pH-sensitive thiol-containing chitosan beads ...
Jayakumar, R.; Reis, R. L.; Mano, J. F.The aim of this study was to develop chitosan-based materials in drug delivery systems possessing covalent attachment of thiol moieties. Thiol-containing chitosan (TCS), found to be soluble in water, was synthesized by graft copolymerization technique. The TCS beads were prepared by using tripolyphoshate, at pH 4.0. The morphology of TCS beads was examined by scanning electron microscopy. The in vitro drug rele...
Chemistry and applications of phosphorylated chitin and chitosan
Jayakumar, R.; Reis, R. L.; Mano, J. F.Chitin and chitosan are natural based non-toxic, biodegradable and biocompatible polymers and have been used in biomedical areas in the form of sutures, wound healing materials and artificial skin, and for the sustained release of drugs as well as in various industrial applications. However, practical use of these polymers has been mainly confined to the unmodified forms. Recently, there has been a growing inte...
Phosphorous containing chitosan beads for controlled oral drug delivery
Jayakumar, R.; Reis, R. L.; Mano, J. F.Phosphorous containing chitosan (PCTS) was synthesized by a graft copolymerization technique in order to be used as controlled drug delivery devices. To test this potential, PCTS beads were prepared by using tripolyphosphate, at pH 4.0 and characterized by scanning electron microscopy. The in vitro drug release behavior in various pH solutions was studied using indomethacin (IM) as a model drug at two different...
Graft copolymerized chitosan : present status and applications
Jayakumar, R.; Prabaharan, M.; Reis, R. L.; Mano, J. F.Chitosan is a natural based polymer obtained by alkaline deacetylation of chitin, exhibiting excellent biological properties such as biodegradation in the human body, and immunological, antibacterial, and wound-healing activity. Chitosan has also been found to be a good candidate as a support material for gene delivery, cell culture and tissue engineering. However, practical use of chitosan has been mainly conf...
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