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Influence of the APOE genotypes in some atherosclerotic risk factors
Martins, M. Carmo; Lima Faleiro, L.; Rodrigues, M.O.; Albergaria, I.; Fonseca, A.The aim of this work was to study the distribution of apolipoprotein E (APOE) genotypes and their association with some atherosclerotic risk factors, all of them modifiable: total, HDL and LDL cholesterol, triglycerides, systolic and diastolic blood pressure, BMI, waist circumference and smoking. The sample population was constituted of 672 healthy subjects recruited in the Lisbon area. Lipids were quantified b...
APOE genotypes and dyslipidemias in a sample of the Portuguese population
Rodrigues, M.O.; Fonseca, A.; Dias, Carlos Matias; Albergaria, I.; Martins, G.; Alpendre, M.L.; Martins, M. do C.The objective of this work was to study the distribution of apolipoprotein E (APOE) genotypes in a sample of the Portuguese population, and its association with the dyslipidemias observed. Study participants were healthy users of local Public Health Laboratories in six regions of mainland Portugal (Porto, Vila Real, Viseu, Lisboa, Portalegre and Faro). A total of 779 men and 1153 women aged 15-74 years agreed t...
Glucose-6-phosphate dehydrogenase deficiency in Portugal: biochemical and mutat...
Rodrigues, M.O.; Freire, A.P.; Martins, G.; Pereira, J.; Martins, M.C.; Monteiro, C.Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzymopathy. This deficiency in erythrocytes has a prevalence of 0.51 +/- 0.109 in the Caucasoid male population of Portugal. The frequency for deficiency-conferring genes is 0.39% in the Portuguese population. In the herein study populations males from areas of Portugal presenting with the highest prevalence of G6PD deficiency (Castel...
Hereditary anaemias in Portugal: epidemiology, public health significance, and ...
Martins, M.C.; Olim, G.; Melo, J.; Magalhães, H.A.; Rodrigues, M.O.A countrywide prospective study aimed at establishing the prevalence of the haemoglobinopathy genes in the Portuguese population was carried out by screening 15,208 randomly selected blood samples from young males. This male based survey provided the opportunity of assessing simultaneously the prevalence of the red cell enzyme glucose-6-phosphate dehydrogenase (G6PD) deficiency, thus giving a picture of these i...
Lipids in children and young people. A public health problem.
Martins, M C; Laboratório de Química Clínica, Instituto Nacional de Saúde, Lisboa.; Rodrigues, M O; Gomes, M A; Fonseca, A; Faleiro, L LCardiovascular diseases represent an important Public Health problem among us. It is known that the atherosclerotic process on which they are based is mostly dependent on hyperlipidemia, mainly of those characterized by hypercholesterolemia and starts early in childhood. In this paper some lipid parameters were evaluated in children and youngsters and the prevalence of those at risk was compared with the one fo...
The Program of External Quality Evaluation in Clinical Chemistry. An overview a...
Martins, M C; Instituto Nacional de Saúde, Lisboa/Porto.; Rodrigues, M O; Gomes, M A; Fonseca, A; Freitas, M M; Miguel, J P; Gomes, E MAfter an eleven-year period, the goals and way of functioning are remembered the External Quality Assessment Scheme in Clinical Chemistry, under the responsibility of the National Institute of Health. The authors try to evaluate the quality of results obtained at the time by the 160 participant laboratories, belonging to the public and private sectors as well as to the Portuguese reference laboratories which ha...
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