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A calcium phosphate coated biphasic scaffold for periodontal complex regeneration
Vaquette, C.; Costa, P. F.; Hamlet, S.; Reis, R. L.; Ivanovski, S.; Hutmacher, D. W.Periodontitis is a common infectious disease that results in the degradation of the supporting tissues around teeth, which if left untreated can lead to tooth loss in the later stages of the disease. We have developed a biphasic scaffold for simultaneous regeneration of the alveolar bone and the periodontal ligament (PDL). This study represents a step forward into the optimization of this scaffold by utilizing ...
A comparative analysis of scaffold material modifications for load-bearing appl...
Chim, H.; Hutmacher, D. W.; Chou, A.; Oliveira, A. L.; Reis, R. L.; Lim, T. C.; Schantz, J. T.To facilitate optimal application of appropriate scaffold architectures for clinical trials, there is a need to compare different scaffold modifications under similar experimental conditions. In this study was assessed the effectiveness of poly-e-caprolactone (PCL) scaffolds fabricated by fused deposition modelling (FDM), with varying material modifications, for the purposes of bone tissue engineering. The inco...
Osteogenic induction of human bone marrow-derived mesenchymal progenitor cells ...
Endres, M.; Hutmacher, D. W.; Salgado, A. J.; Kaps, C.; Ringe, J.; Reis, R. L.; Sittinger, M.; Brandwood, A.; Schantz, J. T.The aim of this project was to investigate the in vitro osteogenic potential of human mesenchymal progenitor cells in novel matrix architectures built by means of a three-dimensional bioresorbable synthetic framework in combination with a hydrogel. Human mesenchymal progenitor cells (hMPCs) were isolated from a human bone marrow aspirate by gradient centrifugation. Before in vitro engineering of scaffold-hMPC c...
Preliminary study on the adhesion and proliferation of human osteoblasts on sta...
Salgado, A. J.; Gomes, Manuela E.; Chou, A.; Coutinho, O. P.; Reis, R. L.; Hutmacher, D. W.Up to today, several techniques have been used to produce biodegradable porous scaffolds for tissue engineering. In this work, a new technique based on extrusion by using blowing agents in combination with a 50:50 (wt.%) blend of starch/cellulose acetate (SCA) was studied. The results show that by using this technique it was possible to obtain scaffolds with 70% of porosity and a fully interconnected network of...
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