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Tauroursodeoxycholic acid prevents Bax-induced membrane perturbation and cytoch...
Rodrigues, Cecília M. P.; Solá, Susana; Sharpe, Juanita C.; Moura, José J. G.; Steer, Clifford J.Biochemistry, 2003, 42 (10), pp 3070–3080 DOI: 10.1021/bi026979d ; Bax is a potent pro-apoptotic member of the Bcl-2 protein family that localizes to the mitochondrial membrane during apoptosis. Tauroursodeoxycholic acid (TUDCA) modulates the apoptotic threshold, in part, by preventing Bax translocation both in vitro and in vivo. The mechanisms by which Bax induces and TUDCA inhibits release of cytochrome c ar...
Bilirubin directly disrupts membrane lipid polarity and fluidity, protein order...
Moura, José J. G.; Rodrigues, Cecília M. P.; Solá, Susana; Brito, Maria A.; Brites, DoraBackground/Aims: Unconjugated bilirubin (UCB) impairs crucial aspects of cell function and induces apoptosis in primary cultured neurones. While mechanisms of cytotoxicity begin to unfold, mitochondria appear as potential primary targets. Methods: We used electron paramagnetic resonance spectroscopy analysis of isolated rat mitochondria to test the hypothesis that UCB physically interacts with mitochondria to i...
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