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Relatório de estágio : Dunster House, Inglaterra
Rodrigues, Cecília Marlene de AscensãoO presente relatório propõe-se analisar o trabalho prático e de pesquisa levados a cabo durante um estágio de 6 meses no departamento de Marketing, na empresa Dunster House. A análise remete, numa primeira instância, para a contextualização da empresa, indústria onde atua, bem como segmentação de clientes. A questão central prende-se com os principais canais de comunicação, nomeadamente as feiras, como parte in...
Incidência e factores associados à infecção nosocomial em Unidades de Medicina ...
Rodrigues, Cecília MariaMestrado em Saúde Pública ; Master Degree Course in Public Health
Inactivation of Escherichia coli in water by TiO2-assisted disinfection using s...
Rodrigues,Cecília P.; Ziolli,Roberta L.; Guimarães,José R.TiO2-assisted heterogeneous photocatalysis and photolysis were evaluated for the disinfection of water samples using a glass reactor with immobilized TiO2 (catalyst), solar light and E. coli as an indicator microorganism of the efficiency of disinfection. Parameters such as color and turbidity of the water, level of coliform bacteria (by the Colilert® method), inclination angle of the solar reactor, solar light...
Tauroursodeoxycholic acid prevents Bax-induced membrane perturbation and cytoch...
Rodrigues, Cecília M. P.; Solá, Susana; Sharpe, Juanita C.; Moura, José J. G.; Steer, Clifford J.Biochemistry, 2003, 42 (10), pp 3070–3080 DOI: 10.1021/bi026979d ; Bax is a potent pro-apoptotic member of the Bcl-2 protein family that localizes to the mitochondrial membrane during apoptosis. Tauroursodeoxycholic acid (TUDCA) modulates the apoptotic threshold, in part, by preventing Bax translocation both in vitro and in vivo. The mechanisms by which Bax induces and TUDCA inhibits release of cytochrome c ar...
Membrane structural changes support the involvement of mitochondria in the bile...
Solá, Susana; Brito, Maria A.; Brites, Dora; Moura, José J. G.; Rodrigues, CecíliaClin Sci (Lond). 2002 Nov;103(5):475-85 ; The accumulation of toxic bile salts within the hepatocyte plays a key role in organ injury during liver disease. Deoxycholate (DC) and glycochenodeoxycholate (GCDC) induce apoptosis in vitro and in vivo, perhaps through direct perturbation of mitochondrial membrane structure and function. In contrast, ursodeoxycholate (UDC) and its taurine-conjugated form (TUDC) appea...
Bilirubin directly disrupts membrane lipid polarity and fluidity, protein order...
Moura, José J. G.; Rodrigues, Cecília M. P.; Solá, Susana; Brito, Maria A.; Brites, DoraBackground/Aims: Unconjugated bilirubin (UCB) impairs crucial aspects of cell function and induces apoptosis in primary cultured neurones. While mechanisms of cytotoxicity begin to unfold, mitochondria appear as potential primary targets. Methods: We used electron paramagnetic resonance spectroscopy analysis of isolated rat mitochondria to test the hypothesis that UCB physically interacts with mitochondria to i...
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