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Development of nickel-based magnetoliposomes

Liposomes entrapping nickel-based magnetic nanoparticles (magnetoliposomes) were prepared and characterized.

New 1,3-diarylureas linked by C-C Suzuki coupling to the methyl 3-aminothieno[3...

New six fluorescent 1,3-diarylureas linked by C-C Suzuki coupling to the 6-position of the methyl 3-aminothieno[3,2-b]pyridine-2-carboxylate moiety were prepared by reaction of the amino groups on the ortho or meta positions relative to the C-C bond of the Suzuki coupling products, with different para-substituted arylisocyanates (H, OMe, CN), in high to excellent yields. The fluorescence properties of the 1,3-d...

Magnetoliposomes based on nickel/silica core/shell nanoparticles

In this work, magnetic nanoparticles of nickel core with silica shell were prepared by soft chemical methods, using tetraethyl orthosilicate (TEOS) and different surfactants as templating media. These nanoparticles were either covered with a lipid bilayer or entrapped in liposomes.

Fluorescence studies on new potential antitumoral 1,3-diarylurea derivatives in...

Magnetic nanoparticles of magnetite and of nickel core with silica shell were prepared and either covered with a lipid bilayer or entrapped in liposomes, forming magnetoliposomes. New potential antitumoral 1,3-diarylurea derivatives of thieno[3,2-b]pyridines were then encapsulated in liposomes and magnetoliposomes and their photophysical behavior was investigated.

New potential antitumoral di(hetero)arylether derivatives in the thieno[3,2-b]p...

New fluorescent methoxylated di(hetero)arylethers in the thieno[3,2-b]pyridine series were prepared by a copper-catalyzed Ullmann-type C-O coupling of the methyl 3-amino-6-bromothieno[3,2-b]pyridine-2-carboxylate with ortho, meta and para-methoxyphenols, using N,N-dimethylglycine as the ligand and Cs2CO3 as the base. The compounds obtained were tested for their inhibitory growth activity in three human tumor c...

Desenvolvimento de magnetolipossomas baseados em nanopartículas de níquel com c...

Dissertação de mestrado em Biofísica e Bionanossistemas ; Na área biomédica, a nanotecnologia tem produzido avanços significativos no diagnóstico, terapêutica e bioengenharia. As nanopartículas magnéticas são de especial relevância, porque podem ser orientadas e localizadas no local de interesse, através de gradientes de campo magnético externo, usado no tratamento do cancro por hipertermia. Neste trabalho, de...

New potential antitumoral fluorescent tetracyclic thieno[3,2-b]pyridine derivat...

Fluorescence properties of two new potential antitumoral tetracyclic thieno[3,2-b]pyridine derivatives were studied in solution and in liposomes of DPPC (dipalmitoyl phosphatidylcholine), egg lecithin (phosphatidylcholine from egg yolk; Egg-PC) and DODAB (dioctadecyldimethylammonium bromide). Compound 1, pyrido[2',3':3,2]thieno[4,5-d]pyrido[1,2-a]pyrimidin-6-one, exhibits reasonably high fluorescence quantum yi...

Fluorescence studies on new potential antitumoral 1,3-diarylurea derivatives of...

Interaction of benzothienoquinolines with DNA and lipid membranes monitored by ...

RICI4 - Book of Abstracts

New potential antitumoral fluorescent tetracyclic thieno[3,2-b]pyridine derivat...