Encontrados 14 documentos, a visualizar página 1 de 2
Using C. elegans to decipher the cellular and molecular mechanisms underlying ...
Bessa, C.; Maciel, P.; Rodrigues, Ana JoãoProva tipográfica (uncorrected proof) ; Neurodevelopmental disorders such as epilepsy, intellectual disability (ID), and autism spectrum disorders (ASDs) occur in over 2 % of the population, as the result of genetic mutations, environmental factors, or combination of both. In the last years, use of large-scale genomic techniques allowed important advances in the identification of genes/loci associated with the...
Gestational protein restriction induces CA3 dendritic atrophy in dorsal hippoca...
Lopes, A.; Torres, D. B.; Rodrigues, Ana João; Cerqueira, João; Pêgo, José M.; Sousa, Nuno; Gontijo, J. A. R.; Boer, P. A.Studies have demonstrated that nutrient deficiency during pregnancy or in early postnatal life results in structural abnormalities in the offspring hippocampus and in cognitive impairment. In an attempt to analyze whether gestational protein restriction might induce learning and memory impairments associated with structural changes in the hippocampus, we carried out a detailed morphometric analysis of the hippo...
Glucocorticoid programing of the mesopontine cholinergic system
Borges, Sónia Maria de Sousa; Coimbra, Bárbara Guimarães Salazar; Cunha, Carina Isabel Soares da; Silva, Ana Paula Ventura; Pinto, LuísaStress perception, response, adaptation, and coping strategies are individually distinct, and the sequel of stress and/or glucocorticoids (GCs) is also distinct between subjects. In the last years, it has become clear that early life stress is a powerful modulator of neuroendocrine stress-responsive circuits, programing intrinsic susceptibility to stress, and potentiating the appearance of stress-related disord...
The future is now : early life events preset adult behaviour
Patchev, Alexandre Vladimirov; Rodrigues, Ana João; Sousa, NunoTo consider the evidence that human and animal behaviours are epigenetically programmed by lifetime experiences. Extensive PubMed searches were carried out to gain a broad view of the topic, in particular from the perspective of human psychopathologies such as mood and anxiety disorders. The selected literature cited is complemented by previously unpublished data from the authors' laboratories. Evidence that ph...
Unveiling the effects of the secretome of mesenchymal progenitors from the umbi...
Silva, Nuno; Rodrigues, Ana João; Sousa, Nuno; Salgado, A. J.; Fraga, J. S.; Reis, R. L.; Manadas, B.It has been previously shown that the secretome of Human Umbilical Cord Perivascular Cells (HUCPVCs), known for their mesenchymal like stem cell character, is able to increase the metabolic viability and hippocampal neuronal cell densities. However, due to the different micro-environments of the distinct brain regions it is important to study if neurons isolated from different areas have similar, or opposite, r...
Dopaminergic modulation of affective and social deficits induced by prenatal gl...
Borges, Sónia Maria de Sousa; Coimbra, Bárbara Guimarães Salazar; Cunha, Carina Isabel Soares da; Pêgo, José M.; Sousa, Nuno; Rodrigues, Ana JoãoPrenatal stress or exposure to elevated levels of glucocorticoids (GCs) can impair specific neurobehavioral circuits leading to alterations in emotional processes later in life. In turn, emotional deficits may interfere with the quality and degree of social interaction. Here, by using a comprehensive behavioral approach in combination with the measurement of ultrasonic vocalizations, we show that in utero GC (i...
Behavioral characterization of the 6-hydroxidopamine model of Parkinson's disea...
Carvalho, Miguel; Campos, Filipa L.; Coimbra, Bárbara Guimarães Salazar; Pêgo, José M.; Lima, Rui; Rodrigues, Ana João; Sousa, Nuno; Salgado, António J.BACKGROUND: Parkinson's disease (PD) is a chronic neurodegenerative condition that is characterized by motor symptoms as a result of dopaminergic degeneration, particularly in the mesostriatal pathway. However, in recent years, a greater number of clinical studies have focused on the emergence of non-motor symptoms in PD patients, as a consequence of damage on the mesolimbic and mesocortical dopaminergic netwo...
The bed nucleus of stria terminalis and the amygdala as targets of antenatal gl...
Oliveira, Mário; Rodrigues, Ana João; Leão, Pedro; Cardona, Diana; Pêgo, José M.; Sousa, NunoRationale: Several human and experimental studies have shown that early life adverse events can shape physical and mental health in adulthood. Stress or elevated levels of glucocorticoids (GCs) during critical periods of development seem to contribute for the appearance of neurospyschiatric conditions such as anxiety and depression, albeit the underlying mechanisms remain to be fully elucidated. Objectives: The...
Mechanisms of initiation and reversal of drug-seeking behavior induced by prena...
Rodrigues, Ana João; Leão, Pedro; Pêgo, José M.; Cardona, Diana; Carvalho, M.; Oliveira, Mário; Costa, Bruno Marques; Carvalho, Ana FrankyWe would like to thank the members of the Neuroscience Research Domain at ICVS for all the helpful discussions and suggestions. We are especially thankful to the animal facility caretakers, and to Drs Sara Silva, António Melo and Ana Paula Silva and Dieter Fischer for their help ; Stress and exposure to glucocorticoids (GC) during early life render individuals vulnerable to brain disorders by inducing structur...
Absence of ataxin-3 leads to enhanced stress response in C. elegans
Rodrigues, Ana João; Carvalho, Andreia Neves; Castro, Andreia Cristiana Teixeira de; Rokka, Anne; Corthals, Gary; Logarinho, Elsa; Maciel, P.Ataxin-3, the protein involved in Machado-Joseph disease, is able to bind ubiquitylated substrates and act as a deubiquitylating enzyme in vitro, and it has been involved in the modulation of protein degradation by the ubiquitinproteasome pathway. C. elegans and mouse ataxin-3 knockout models are viable and without any obvious phenotype in a basal condition however their phenotype in stress situations has never...
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