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Unveiling the effects of the secretome of mesenchymal progenitors from the umbi...

It has been previously shown that the secretome of Human Umbilical Cord Perivascular Cells (HUCPVCs), known for their mesenchymal like stem cell character, is able to increase the metabolic viability and hippocampal neuronal cell densities. However, due to the different micro-environments of the distinct brain regions it is important to study if neurons isolated from different areas have similar, or opposite, r...

Desempenho motor. Um estudo normativo e criterial em crianças da Região Autónom...

O objectivo central do presente estudo foi construir valores de referência para os ‘skills’ locomotores e de controlo dos objectos em crianças da Região Autónoma da Madeira, Portugal. A amostra envolveu 853 sujeitos, 426 rapazes e 427 raparigas, que participaram na pesquisa ‘Crescer com Saúde na Região Autónoma da Madeira’. Os ‘skills’ motores fundamentais foram avaliados através do ‘Test of Gross Motor Develop...

Effects of acid-base imbalance on vascular reactivity

Acid-base homeostasis maintains systemic arterial pH within a narrow range. Whereas the normal range of pH for clinical laboratories is 7.35-7.45, in vivo pH is maintained within a much narrower range. In clinical and experimental settings, blood pH can vary in response to respiratory or renal impairment. This altered pH promotes changes in vascular smooth muscle tone with impact on circulation and blood pressu...

Metabolic syndrome and obesity in children and adolescents (3-15 years) from Ma...

Cardiovascular diseases ICVO) are the first cause Df morbidi1y and mortality af world levei. CVD appears mostly associafed to a group cf Iodors such os hypertension, dyslipidemio, eleYoted plasmo glucose ond obesity, whose constellotion hos been nomed the metobolic syndrome IMelSl. The purposes of lhis study were: 01 to determine the prevolence of MelS in o semple of Portuguese children ond odolescents living i...

An activity oriented visual modelling language with automatic translation to di...

The traditional approach for discrete event simulation modelling includes visual support diagrams for modeller-client communication purposes (model interpretation and validation) and also to act as the basis for simulation lan-guage program construction. Although modern simulation packages use powerful graphical interfaces for programming and animation pur-poses, these packages still require enormous simulation...

Ionic radiocontrast inhibits endothelium-dependent vasodilation of the canine r...

To determine if radiocontrast impairs vascular relaxation of the renal artery, segments (4-5 mm in length) of canine renal artery were suspended in vitro in organ chambers to measure isometric force (95% O2/5% CO2, at 37ºC). Arterial segments with and without endothelium were placed at the optimal point of their length-tension relation and incubated with 10 µM indomethacin to prevent synthesis of endogenous pro...

Protective effect of N-acetylcysteine against oxygen radical-mediated coronary ...

The present study investigated the protective effect of N-acetylcysteine (NAC) against oxygen radical-mediated coronary artery injury. Vascular contraction and relaxation were determined in canine coronary arteries immersed in Kreb's solution (95% O2-5% CO2), incubated or not with NAC (10 mM), and exposed to free radicals (FR) generated by xanthine oxidase (100 mU/ml) plus xanthine (0.1 mM). Rings not exposed t...

Case study 11 : a new model for CE in the University of Minho, Portugal