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ET(B2) receptor subtype stimulation relaxes the iris sphincter muscle.

Rocha-Sousa A; Saraiva J; Amaral M; Alves-Faria P; Falcão-Reis F; Leite-Moreira AF




Inotropic and lusitropic effects of ghrelin and their modulation by the endocar...

Soares, JB; Rocha-Sousa, A; Castro-Chaves, P; Henriques-Coelho, T; Leite-Moreira, AF

Contractile effects of ghrelin (10(-9) to 10(-6) M) were tested in rat papillary muscles of normal (n = 50) and hypertrophic (n = 16) right ventricles (RV). RV hypertrophy was induced by pulmonary hypertension using monocrotaline. In normal muscles, ghrelin was added either alone (n = 9) or after pre-treatment with indomethacin (cycloxygenase inhibitor, 10(-5) M; n = 10), L-nitro-L-arginin (NO synthase inhibito...


Ghrelin as a novel locally produced relaxing peptide of the iris sphincter and ...

Rocha-Sousa, A; Saraiva, J; Henriques-Coelho, T; Falcão-Reis, F; Correia-Pinto, J; Leite-Moreira, AF

Ghrelin is a recently described acylated peptide, which works as a somatosecretagogue and has described effects on the smooth, skeletal and cardiac muscle. We examined the production and effects of ghrelin on relaxation of the iris muscles. Contractile effects of 1-5 human ghrelin (frGhr, 10(-9)-6 x 10(-5)M) and 1-5 human des-octanoyl-ghrelin (d-frGhr; 10(-9)-6 x 10(-5)M) were tested on iris rabbit sphincter (n...


Contractile effects of Ghrelin and expression of its receptor GHS-R1a in normal...

Soares, JB; Rocha-Sousa, A; Castro-Chaves, P; Henriques-Coelho, T; Roncon-Albuquerque R, Jr.; Leite-Moreira, AF

INTRODUCTION: Ghrelin, isolated in 1999, is an endogenous ligand for the growth hormone secretagogue receptor (GHS-R1a). Recent studies suggest that it may influence the function of normal and failing hearts. Nonetheless, it has been difficult to differentiate its effects on the intrinsic properties of the myocardium from the secondary effects resulting from growth hormone release and vasomotor action. This stu...


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Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia