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Optimization of fed-batch fermentation processes with bio-inspired algorithms

Rocha, Miguel; Mendes, Rui; Rocha, Orlando; Rocha, I.; Ferreira, E. C.

The optimization of the feeding trajectories in fed-batch fermentation processes is a complex problem that has gained attention given its significant economical impact. A number of bio-inspired algorithms have approached this task with considerable success, but systematic and statistically significant comparisons of the different alternatives are still lacking. In this paper, the performance of different metahe...


Saúde para todos: relatório de projeto de intervenção em saúde mental na comuni...

Rocha, Orlando José Santos

Dissertação de mestrado em Enfermagem comunitária, orientada por Helena Maria Guerreiro José, co-orientada por Maria Manuela Narciso Pereira, Instituto Politécnico de Beja, Escola Superior de Saúde, 2012.


Saúde para todos: relatório de projeto de intervenção em saúde mental na comuni...

Rocha, Orlando José Santos

Dissertação de mestrado em Enfermagem comunitária, orientada por Helena Maria Guerreiro José, co-orientada por Maria Manuela Narciso Pereira, Instituto Politécnico de Beja, Escola Superior de Saúde, 2012.

Data: 2012   |   Origem: Repositório Comum

Comparison of adsorption equilibrium of fructose, glucose and sucrose on potass...

Nobre, Clarisse; Santos, M.J.; Dominguez, Ana; Torres, Duarte; Rocha, Orlando; Peres, António M.; Rocha, Isabel; Ferreira, Eugénio C.; Teixeira, José A.

Adsorption equilibrium of fructose, glucose and sucrose was evaluated on sulfonated poly(styrene-codivinylbenzene) cation-exchange resins. Two types of resins were used: potassium (K+) gel-type and sodium (Na+) macroporous resins. Influence of the cation and effect of the resin structure on adsorption were studied. The adsorption isotherms were determined by the static method in batch mode for monocomponent and...

Data: 2010   |   Origem: Biblioteca Digital do IPB

Comparison of adsorption equilibrium of fructose, glucose and sucrose on potass...

Nobre, C.; Santos, Maria João; Dominguez, Ana; Torres, D.; Rocha, Orlando; Peres, A. M.; Rocha, I.; Ferreira, E. C.; Teixeira, J. A.; Rodrigues, L. R.

Adsorption equilibrium of fructose, glucose and sucrose was evaluated on sulfonated poly(styrene-co-divinylbenzene) cation-exchange resins. Two types of resins were used: potassium (K+) gel-type and sodium (Na+) macroporous resins. Influence of the cation and effect of the resin structure on adsorption were studied. The adsorption isotherms were determined by the static method in batch mode for mono-component a...


A dynamical model for the fermentative production of fructooligosaccharides

Rocha, Orlando; Nobre, C.; Dominguez, Ana; Torres, D.; Faria, Nuno; Rodrigues, L. R.; Teixeira, J. A.; Ferreira, E. C.; Rocha, I.

In this paper a detailed mathematical model is presented for the fermentative production of fructo-oligosaccharides with Aspergillus sp. The model accounts for hydrolysis and transfructolization reactions, as well as biomass formation and it contains 27 parameters that were determined from experimental data using a System Biology toolbox with the Simulated Annealing method for curve fitting. Several additional ...


Desenvolvimento de ferramentas computacionais para a optimização de processos d...

Rocha, Orlando

Tese de mestrado em Informática ; Actualmente, uma larga variedade de produtos tais como antibióticos, proteínas, vacinas e outros compostos químicos são produzidos através de processos fermentativos. Devido à subida dos preços do petróleo e aos fortes incentivos por parte das instituições para substituir os produtos derivados de petróleo por “produtos verdes”, muitos dos processos tradicionais têm vindo a ser...


UV spectrophotometry method for the monitoring of galacto-oligosaccharides prod...

Dias, Luís G.; Veloso, Ana C. A.; Correia, Daniela M.; Rocha, Orlando; Torres, D.; Rocha, I.; Rodrigues, L. R.; Peres, A. M.

Monitoring the industrial production of galacto-oligosaccharides (GOS) requires a fast and accurate methodology able to quantify, in real time, the substrate level and the product yield. In this work, a simple, fast and inexpensive UV spectrophotometric method, together with partial least squares regression (PLS) and artificial neural networks (ANN), was applied to simultaneously estimate the products (GOS) and...


Application of image analysis to the prediction of EBC barley kernel weight dis...

Amaral, A. L.; Rocha, Orlando; Gonçalves, Cristina; Ferreira, António Augusto; Ferreira, E. C.

It is known that the barley kernel size is an important factor regarding the uniformity of the malting and brewery processes, barley valuation, approval andmarket value. In order to facilitate the barley purchasing process, a fast field technique for kernel size evaluation, such as the image analysis technique proposed in this work, would be greatly appreciated as a fast and simple procedure for barley selectio...


Optimization of a fructooligosaccharides purification method using activated ch...

Nobre, C.; Dominguez, Ana; Torres, D.; Rocha, Orlando; Rocha, I.; Ferreira, E. C.; Teixeira, J. A.; Rodrigues, L. R.

Fructooligosaccharides (FOS) have gained large commercial interest due to its beneficial properties in the human health as prebiotics. FOS are produced industrially by fermentative processes. However, the result of such fermentations is a complex mixture containing salts and approximately 50% (w/w) of low molecular weight sugars that have to be eliminated. Among other techniques that have been studied, the adso...


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    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia