Encontrados 122 documentos, a visualizar página 1 de 13
A obra no gerúndio
Rocha, Miguel Ângelo, 1964-Tese de doutoramento, Belas-Artes (Instalação), Universidade de Lisboa, Faculdade de Belas-Artes, 2014 ; O presente texto parte do estudo das questões introduzidas pela arte processual dos anos 60/70, do século XX, com o intuito de verificar uma performatividade visual que activa um tempo gerúndio contido na obra. A partir dos conceitos de duração, intuição, imagem e criação de Henri Bergson, articulados com a...
Optimization of fed-batch fermentation processes with bio-inspired algorithms
Rocha, Miguel; Mendes, Rui; Rocha, Orlando; Rocha, I.; Ferreira, E. C.The optimization of the feeding trajectories in fed-batch fermentation processes is a complex problem that has gained attention given its significant economical impact. A number of bio-inspired algorithms have approached this task with considerable success, but systematic and statistically significant comparisons of the different alternatives are still lacking. In this paper, the performance of different metahe...
Reconciling gene expression data with regulatory network models – a stimulon-ba...
Faria, José P.; Overbeek, Ross; Taylor, Ronald C.; Goelzer, Anne; Fromion, Vincent; Rocha, Miguel; Rocha, I.; Henry, Christopher S.The reconstruction of genome-scale metabolic models from genome annotations has become a routine practice in Systems Biology research. The potential of metabolic models for predictive biology is widely accepted by the scientific community, but these same models still lack the capability to account for the effect of gene regulation on metabolic activity. Our focus organism, Bacillus subtilis is most commonly fou...
A de novo complex chromosome rearrangement (CCR) involving chromosome 5, 6 and 15
Candeias, Cristina; Mota Freitas, Manuela; Magalhães, Sara; Rocha, Miguel; Marques, Bárbara; Correia, Hildeberto; Oliva Teles, NatáliaAbstrat publicado em: Chromosome Research. 2003;21(Suppl 1):S1–S168. doi:10.1007/s10577-013-9364-x
Email spam detection : a symbiotic feature selection approach fostered by evolu...
Sousa, Pedro; Cortez, Paulo, 1971-; Vaz, Rui Fernando Martins; Rocha, Miguel; Rio, MiguelPost-print version (prior to journal publication) ; The electronic mail (email) is nowadays an essential communication service being widely used by most Internet users. One of the main problems affecting this service is the proliferation of unsolicited messages (usually denoted by spam) which, despite the efforts made by the research community, still remains as an inherent problem affecting this Internet servi...
TNA4OptFlux : a software tool for the analysis of strain optimization strategies
Pinto, José P.; Pereira, Rui; Cardoso, João; Rocha, I.; Rocha, MiguelBACKGROUND:Rational approaches for Metabolic Engineering (ME) deal with the identification of modifications that improve the microbes' production capabilities of target compounds. One of the major challenges created by strain optimization algorithms used in these ME problems is the interpretation of the changes that lead to a given overproduction. Often, a single gene knockout induces changes in the fluxes of s...
An integrated framework for strain optimization
Maia, Paulo; Rocha, I.; Rocha, MiguelThe identification of genetic modifications leading to mutant strains able to overproduce compounds of industrial interest is a challenging task in Metabolic Engineering (ME). Several methods have been proposed but, to some extent, none of them is suitable for all the specificities of each particular strain optimization problem. This work proposes an integrated framework that allows its users to configure and f...
Evolutionary computation for predicting optimal reaction knockouts and enzyme m...
Evangelista, Pedro; Rocha, Miguel; Rocha, I.One of the main purposes of Metabolic Engineering is the quantitative prediction of cell behaviour under selected genetic modifications. These methods can then be used to support adequate strain optimization algorithms in a outer layer. The purpose of the present study is to explore methods in which dynamical models provide for phenotype simulation methods, that will be used as a basis for strain optimization a...
A educação geográfica e histórica na assunção da cidadania : estudo de caso com...
Rocha, Miguel Ângelo Alves Gomes Pinho daEducar para a cidadania é fundamental na Contemporaneidade, dada a complexidade sociocultural em que vivemos. Urge, assim, uma formação do caráter dos nossos alunos, transversal a todas as disciplinas e níveis de ensino, promovendo-se os ideais democráticos, baseados na universalidade dos direitos e deveres humanos. Como tal, cabe ao professor, levar os discentes à adoção de boas condutas, na medida em que este...
Electroforese bidimensional no cancro colo-rectal em hipóxia e normóxia: Optimi...
Rocha, Miguel Quesado daO carcinoma colo-rectal é o terceiro tipo de cancro mais diagnosticado nos homens e o segundo nas mulheres em todo o mundo. Em Portugal, é o segundo mais incidente, logo a seguir ao cancro da próstata nos homens e ao da mama nas mulheres. A hipóxia tumoral, estado de reduzida pressão parcial de oxigénio nos tecidos, constitui uma das principais causas de resistência ao tratamento anti-tumoral. Esta condição est...
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