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Familial pseudoxanthoma elasticum with nephrocalcinosis: a case report
Lacerda, P.; Beirão, I.; Pestana, P.; Beirão, J.M.; Freitas, C.; Rocha, M.J.; Cabrita, A.; Costa, P.P.Pseudoxanthoma elasticum (PXE) is an autosomal recessive genetic disorder characterized by progressive calcification and fragmentation of elastic fibres. PXE commonly involves the reticular dermis, the Bruch membrane of the eye, and blood vessels. PXE is caused by mutations in the ABCC6 gene. More than 300 pathogenic ABCC6 mutations are known. Two of these mutations are common: p.R1141X in exon 24, with a preva...
Lamotrigine pharmacokinetic evaluation in epileptic patients submitted to VEEG ...
Almeida, A. M.; Falcão, A. C.; Sales, F.; Baldeiras, I.; Rocha, M. J.; Caramona, M. M.Objective: The aim of the present study was to evaluate the pharmacokinetic profile of lamotrigine (LTG) in epileptic patients submitted to video-electroencephalography (VEEG) monitoring and, in addition, to investigate the influence of concomitant antiepileptic drugs (AEDs) on the kinetics of LTG. Methods: The analysis assumed a one-compartment open model with first-order absorption and elimination. The kineti...
Lamotrigine pharmacokinetic evaluation in epileptic patients submitted to VEEG ...
Almeida, A. M.; Falcão, Amílcar; Sales, F.; Baldeiras, I.; Rocha, M. J.; Caramona, M. M.Objective: The aim of the present study was to evaluate the pharmacokinetic profile of lamotrigine (LTG) in epileptic patients submitted to video-electroencephalography (VEEG) monitoring and, in addition, to investigate the influence of concomitant antiepileptic drugs (AEDs) on the kinetics of LTG. Methods: The analysis assumed a one-compartment open model with first-order absorption and elimination. The kineti...
Monitoring serum levels of gentamicin in neonates.
Rocha, M J; Almeida, A M; Afonso, E; Martins, V; Leitão, F; Santos, J; Falcão, A CNewborn infants in intensive care units demonstrated a higher incidence of gestational age below 31 week. Obstetrical and neonatal diseases procedures required for the management of critically ill neonates are associated with an increased risk of infections. Gentamicin is an aminoglycoside antibiotic often used to treat gram-negative bacillary infections and suspected sepsis in neonates. The risk of toxicity or...
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