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Cellular hypomethylation is associated with impaired nitric oxide production by...
Barroso, M.; Rocha, M. S.; Esse, R.; Gonçalves, I. Jr; Gomes, Anita Q.; Teerlink, T.; Jakobs, C.; Blom, H. J.; Loscalzo, J.; Rivera, I.Hyperhomocysteinemia (HHcy) is a risk factor for vascular disease, but the underlying mechanisms remain incompletely defined. Reduced bioavailability of nitric oxide (NO) is a principal manifestation of underlying endothelial dysfunction, which is an initial event in vascular disease. Inhibition of cellular methylation reactions by S-adenosylhomocysteine (AdoHcy), which accumulates during HHcy, has been suggest...
Data: 2012
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Origem: Repositório Científico do Instituto Politécnico de Lisboa
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