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Oligoclonal IgG bands in the cerebrospinal fluid of portuguese patients with mu...
Sá,Maria José; Sequeira,Lucinda; Rio,Maria Edite; Thompson,Edward J.We assessed the frequency of cerebrospinal fluid (CSF) restricted oligoclonal IgG bands (IgG-OCB) in Portuguese multiple sclerosis (MS) patients and its relationship with outcome. Paired CSF/serum samples of 406 patients with neurological disorders were submitted to isoelectric focusing with immunodetection of IgG. Ninety-two patients had definite MS; non-MS cases were assembled in groups inflammatory/infectiou...
Genotypes at the APOE and SCA2 loci do not predict the course of multiple scler...
Santos, Mónica; Costa, Maria do Carmo; Rio, Maria Edite; Sá, Maria José; Monteiro, Marta; Valença, Angela; Sá, Alfredo; Dinis, José; Figueiredo, JoséProva tipográfica (In Press) ; Multiple sclerosis (MS) is a demyelinating disease that affects about one in 500 young Europeans. In order to test the previously proposed influence of the APOE and SCA2 loci on susceptibility to MS, we studied these loci in 243 Portuguese patients and 192 healthy controls and both parents of 92 patients. We did not detect any significant difference when APOE and SCA2 allele freq...
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