Encontrados 14 documentos, a visualizar página 1 de 2
Neutrophil gelatinase-associated lipocalin in kidney transplantation is an earl...
Fonseca, I.; Oliveira, J.; Almeida, M.; Cruz, M.; Malho, A.; Martins, L.; Dias, L.; Pedroso, S.; Santos, J.; Lobato, L.; Castro-Henriques, A.Urinary neutrophil gelatinase-associated lipocalin (uNGAL) has been suggested as potential early marker of delayed graft function (DGF) following kidney transplantation (KTx). We conducted a prospective study in 40 consecutive KTx recipients to evaluate serial changes of uNGAL within the first week after KTx and assess its performance in predicting DGF (dialysis requirement during initial posttransplant week) a...
Modelling competing risks in nephrology research: an example in peritoneal dial...
Teixeira, L.; Rodrigues, A.; Carvalho, M.; Cabrita, A.; Mendonça, D.BACKGROUND: Modelling competing risks is an essential issue in Nephrology Research. In peritoneal dialysis studies, sometimes inappropriate methods (i.e. Kaplan-Meier method) have been used to estimate probabilities for an event of interest in the presence of competing risks. In this situation a competing risk analysis should be preferable. The objectives of this study are to describe the bias resulting from t...
Sentimentos acráticos, empatia e autoconsciência
Mendonça, DBaseado num trabalho de investigação realizado no âmbito do Pós-Doutoramento (SFRH/BPD/14175/2007) e inserida no projecto Fundamentos Cognitivos do Si (PTDC/FIL-FCI/110978/2009) do Instituto de Filosofia da Linguagem ; O presente artigo analisa o papel dos sentimentos acráticos na empatia e na autoconsciência argumentando que os sentimentos acráticos são fundamentais para nos conhecermos e nós próprios e aos o...
Melhoramento do sobreiro para uma regeneração artificial sustentável
Gaspar, Maria J.; Rodrigues, Ana P.; Faria, Carla; Silva, F. Costa e; Merouani, H.; Silva, J. Costa e; Correia, António H.; Rodrigues, J.C.; Graça, J.O sobreiro (Quercus suber) é uma espécie singular devido à sua importância no funcionamento do ecossistema mediterrânico e na produção de cortiça. No entanto, apesar da sua importância ecológica e sócio-económica, pouco se compreende ainda dos seus processos de adaptabilidade às diferentes condições ambientais. Em algumas áreas do mediterrâneo ocidental, as florestas de sobreiro encontram-se em declínio e a man...
Assessing risk factors for migraine: differences in gender transmission
Lemos, C.; Alonso, I.; Barros, J.; Sequeiros, J.; Pereira-Monteiro, J.; Mendonça, D.; Sousa, A.Abstract AIM: Our aim was to assess which specific factors are contributing to an increased risk of migraine in a group of 131 Portuguese families. METHODS: We studied 319 first-degree relatives, using a multilevel approach to account for the dependency among members from the same family. We included in the model relative's gender, the proband's gender and age-at-onset, to evaluate if any of these variables we...
A role for endothelin receptor type A in migraine without aura susceptibility? ...
Lemos, C.; Neto, J.; Pereira-Monteiro, J.; Mendonça, D.; Barros, J.; Sequeiros, J.; Alonso, I.; Sousa, A.Abstract BACKGROUND AND PURPOSE: Migraine is a common neurological disabling disorder, and anomalies of vascular function have been implied in its pathophysiology. Several findings point to a possible role of the endothelin receptor type A (EDNRA) in migraine. We aim to assess the involvement of endothelin receptor type A (EDNRA) in migraine susceptibility in a sample of Portuguese migraineurs. METHODS: Three...
BDNF and CGRP interaction: implications in migraine susceptibility
Lemos, C.; Mendonça, D.; Pereira-Monteiro, J.; Barros, J.; Sequeiros, J.; Alonso, I.; Sousa, A.Abstract OBJECTIVES: Migraine pathophysiology involves several pathways. Our aims were to explore a possible role of the brain-derived neurotrophic factor gene (BDNF) in migraine susceptibility; to study, for the first time, the calcitonin gene-related peptide gene (CGRP); and a possible interaction between the two. METHODS: Using a case-control approach, four tagging single nucleotide polymorphisms (SNPs) (r...
Evidence of syntaxin 1A involvement in migraine susceptibility: a Portuguese st...
Lemos, C.; Pereira-Monteiro, J.; Mendonça, D.; Ramos, E.; Barros, J.; Sequeiros, J.; Alonso, I.; Sousa, A.Abstract OBJECTIVE: To confirm syntaxin 1A as a risk factor for migraine, given that syntaxin 1A interacts with several factors in migraine pathophysiology. DESIGN: Case-control approach. SETTING: An outpatient clinic. PARTICIPANTS: In a sample of 188 migraineurs (111 without aura and 77 with aura) and 287 migraine-free controls, 3 tagging SNPs of STX1A (rs3793243, rs941298, and rs6951030) were analyzed. A b...
Molecular Phylogeny and Phylogeography of Species of Passeriformes (Aves): hist...
Fernando Mendonça D\ HortaNeste trabalho buscou-se contribuir para a compreensão da história biogeográfica das florestas da Região Neotropical e, em particular, da Floresta Atlântica a partir de estudos de diversificação inter e intra-específica de grupos de aves. Para investigar a história biogeográfica das florestas da região neotropical foram sequenciados genes mitocondriais (citb, ND2 e ND3) e nucleares (Fib7) de 102 amostras das se...
Familial clustering of migraine: further evidence from a Portuguese study
Lemos, C.; Castro, M.; Barros, J.; Sequeiros, J.; Pereira-Monteiro, J.; Mendonça, D.; Sousa, A.Abstract OBJECTIVE: Our aim was to evaluate familial aggregation of migraine in a large group of Portuguese families, and to assess if familial aggregation differs between MA and MO. METHODS: Familial aggregation was evaluated by estimating relative risk (RR) of migraine in 143 first-degree relatives of 50 probands with MA, in 196 first-degree relatives of 94 probands with MO and also in proband's spouses. Pr...
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