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Identification of novel nucleus pulposus markers: Interspecies variations and i...
Rodrigues-Pinto, R.; Richardson, S.; Hoyland, J.Mesenchymal stem-cell based therapies have been proposed as novel treatments for intervertebral disc degeneration, a prevalent and disabling condition associated with back pain. The development of these treatment strategies, however, has been hindered by the incomplete understanding of the human nucleus pulposus phenotype and by an inaccurate interpretation and translation of animal to human research. This revi...
Evolution of the thyroid hormone-binding protein, transthyretin
Power, Deborah; Elias, N. P.; Richardson, S. J.; Mendes, J.; Soares, M. C.; Santos, C. R. A.Transthyretin (TTR) belongs to a group of proteins, which includes thyroxine-binding globulin and albumin, that bind to and transport thyroid hormones in the blood. TTR is also indirectly implicated in the carriage of vitamin A through the mediation of retinol-binding protein (RBP). It was first identified in 1942 in human serum and cerebrospinal fluid and was formerly called prealbumin for its ability to migra...
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