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Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X...
Rodrigues, Ricardo J.; Almeida, Teresa; Richardson, Peter J.; Oliveira, Catarina R.; Cunha, Rodrigo A.ATP is released in a vesicular manner from nerve terminals mainly at higher stimulation frequencies. There is a robust expression of ATP (P2) receptors in the brain, but their role is primarily unknown. We report that ATP analogs biphasically modulate the evoked release of glutamate from purified nerve terminals of the rat hippocampus, the facilitation being mediated by P2X1, P2X2/3, and P2X3 [antagonized by 8-...
Adenosine A3 receptors in the rat hippocampus: Lack of interaction with A1 rece...
Lopes, Luísa V.; Rebola, Nelson; Costenla, Ana Rita; Halldner, Linda; Jacobson, Marlene A.; Oliveira, Catarina R.; Richardson, Peter J.Adenosine acts as a neuromodulator in the hippocampus essentially through activation of inhibitory A1 receptors. Using single-cell PCR analysis, we found that CA1 pyramidal cells coexpress A1 receptor mRNA together with that of another adenosine receptor, the A3 receptor. As occurs for the A1 receptor, Western blot analysis indicated that the A3 receptor is also located in hippocampal nerve terminals. However, ...
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