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Molecular characterization of PDGFR-α/PDGF-A and c-KIT/SCF in gliosarcomas
Reis, R. M.; Martins, Albino; Ribeiro, Susana A.; Basto, Diana; Longatto Filho, Adhemar; Schmitt, Fernando C.; Lopes, José M.Gliosarcomas are rare and poorly characterized malignant brain tumors that exhibit a biphasic tissue pattern with areas of gliomatous and sarcomatous differentiation. These tumors are histological variants of glioblastoma, displaying a similar genetic profile and dismal prognosis. Up-regulation of PDGFR subfamily of tyrosine kinase members, PDGFR-α and c-Kit, and their intracellular effectors RAS/RAF/MAPK has a...
Data: 2005
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Origem: RepositóriUM - Universidade do Minho
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