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Adenosine A2A receptors control the extracellular levels of adenosine through m...
Pinto-Duarte, António; Coelho, Joana E.; Cunha, Rodrigo A.; Ribeiro, Joaquim Alexandre; Sebastião, Ana M.Adenosine, a neuromodulator of the CNS, activates inhibitory-A1 receptors and facilitatory-A2A receptors; its synaptic levels are controlled by the activity of bi-directional equilibrative nucleoside transporters. To study the relationship between the extracellular formation/inactivation of adenosine and the activation of adenosine receptors, we investigated how A1 and A2A receptor activation modifies adenosine...
Activation of adenosine A2A receptor facilitates brain-derived neurotrophic fac...
Diógenes, Maria José; Fernandes, Catarina Cunha; Sebastião, Ana Maria; Ribeiro, Joaquim Alexandre©2004 Society for Neuroscience ; Both brain-derived neurotrophic factor (BDNF) and adenosine influence neuronal plasticity. We now investigated how adenosine influences the action of BDNF on synaptic transmission in the CA1 area of the rat hippocampal slices. Alone, BDNF (20 –100 ng/ml) did not significantly affect field EPSPs (fEPSPs). However, a 2 min pulse of high-K+ (10 mM) 46 min before the application of...
Endogenous Adenosine Modulation of 22Na Uptake by Rat Brain Synaptosomes
Ribeiro, Joaquim Alexandre; Lobo, M. Graça B.; Sebastião, Ana M.To evaluate if endogenous extracellular adenosine influences sodium channel activity in nerve terminals, we investigated how manipulations of extracellular adenosine levels influence 22Na uptake by rat brain synaptosomes stimulated with veratridine (VT). To decrease extracellular adenosine levels, adenosine deaminase (ADA) that converts adenosine into an inactive metabolite was used. To increase extracellular a...
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