Encontrados 12 documentos, a visualizar página 1 de 2

Efeitos da maturação sexual nos níveis de pressão arterial em crianças e adoles...

Presynaptic kainate receptors modulating glutamatergic transmission in the rat ...

Kainate receptors are ionotropic glutamate receptors located postsynaptically, mediating frequency-dependent transmission, and presynaptically, modulating transmitter release. In contrast to the excitatory postsynaptic kainate receptors, presynaptic kainate receptor can also be inhibitory and their effects may involve a metabotropic action. Arachidonic acid (AA) modulates most ionotropic receptors, in particula...

Purinergic P2 receptors trigger adenosine release leading to adenosine A2A rece...

Electrophysiological recordings were used to investigate the effects of ATP analogues on [theta]-burst-induced long-term potentiation (LTP) in rat hippocampal slices. [alpha],[beta]-Methylene ATP ([alpha],[beta]-MeATP; 20 [mu]M) decreased LTP from 36±9% to 17±5%, an effect prevented by adenosine A1 receptor blockade in accordance with the localised catabolism of ATP analogues into adenosine, leading to adenosin...

Ecto-AMP Deaminase Blunts the ATP-Derived Adenosine A2A Receptor Facilitation o...

At synapses, ATP is released and metabolised through ecto-nucleotidases forming adenosine, which modulates neurotransmitter release through inhibitory A1 or facilitatory A2A receptors, according to the amounts of extracellular adenosine. Neuromuscular junctions possess an ecto-AMP deaminase that can dissociate extracellular ATP catabolism from adenosine formation. In this study we have investigated the pattern ...

Enhanced adenosine A2A receptor facilitation of synaptic transmission in the hi...

Adenosine either inhibits or facilitates synaptic transmission through A1 or A2A receptors, respectively. Since A2A receptor density increases in the limbic cortex of aged (24 mo) compared with young adult rats (2 mo), we tested if A2A receptor modulation of synaptic transmission was also increased in aged rats. The A2A receptor agonist, CGS21680 (10 nM), caused a larger facilitation of the field excitatory pos...

Patterns of daily physical activity during days in children and adolescents

Assessment of children's and adolescent´s physical activity levels

Adenosine A2A receptor facilitation of hippocampal synaptic transmission is dep...

Adenosine tonically inhibits synaptic transmission through actions at A1 receptors. It also facilitates synaptic transmission, but it is unclear if this facilitation results from pre- and/or postsynaptic A2A receptor activation or from indirect control of inhibitory GABAergic transmission. The A2A receptor agonist, CGS 21680 (10 nM), facilitated synaptic transmission in the CA1 area of rat hippocampal slices (b...

Association of maturation, sex and body fat in cardiorespiratory fitness

Pertussis toxin prevents presynaptic inhibition by kainate receptors of rat hip...

Kainate receptors are ionotropic receptors, also reported to couple to Gi/Go proteins, increasing neuronal excitability through disinhibition of neuronal circuits. We directly tested in hippocampal synaptosomes if kainate receptor-mediated inhibition of GABA release involved a metabotropic action. The kainate analogue, domoate (3 [mu]M), inhibited by 24% [3H]GABA-evoked release, an effect reduced by 76% in syna...