Encontrados 7 documentos, a visualizar página 1 de 1
Response properties of nociceptive neurons in the caudal ventrolateral medulla ...
Ribeiro, Filipa Pinto; Ansah, Osei B.; Almeida, Armando; Pertovaara, AnttiWe characterized response properties of neurons in the caudal ventrolateral medulla (CVLM), a structure involved in pain modulation. Electrophysiological recordings were performed in pentobarbitoneanesthetized control and monoarthritic rats. Noxious pinch, heat, cold and colorectal distension were used for peripheral test stimulation. To study central modulation of CVLM neurons and role in mediating descending ...
Interaction between chronic stress and pain : the HPA axis and potential hypoth...
Ribeiro, Filipa PintoTese de doutoramento em Ciências da Saúde ; Pain is an essential tool for survival, but equally important is the ability to overcome pain in life threatening events, allowing us to react. Stress-induced analgesia exemplifies this concept as a strong acute stressor activates the hypothalamic-pituitary-adrenal glands (HPA) axis and leads to the release of adrenaline, dampening pain processing and resulting in tr...
Motor uncoordination and neuropathology in a transgenic mouse model of Machado-...
Fernandes, Anabela Silva; Costa, Maria do Carmo; Silva, Sara Carina Duarte da; Oliveira, Pedro; Botelho, C. M.; Martins, Lu??s Filipe Forte OliveiraMachado-Joseph disease (MJD) is a late-onset neurodegenerative disorder caused by a polyglutamine (polyQ) expansion in the ataxin-3 protein. We generated two transgenic mouse lineages expressing the expanded human ataxin-3 under the control of the CMV promoter: CMVMJD83 and CMVMJD94, carrying Q83 and Q94 stretches, respectively. Behavioral analysis revealed that the CMVMJD94 transgenic mice developed motor unco...
Antinociception induced by chronic glucocorticoid treatment is correlated to lo...
Almeida, Armando; Ribeiro, Filipa Pinto; P??go, Jos?? M.; Sousa, Nuno; Le??o, Pedro; Moreira, VitorBACKGROUND: While acute effects of stress on pain are well described, those produced by chronic stress are still a matter of dispute. Previously we demonstrated that chronic unpredictable stress results in antinociception in the tail-flick test, an effect that is mediated by increased levels of corticosteroids. In the present study, we evaluated nociception in rats after chronic treatment with corticosterone (C...
Influence of arthritis on descending modulation of nociception from the paraven...
Ribeiro, Filipa Pinto; Ansah, Osei B.; Almeida, Armando; Pertovaara, AnttiWe studied the influence of arthritis on descending modulation of nociception from the hypothalamic paraventricular nucleus (PVN) in the rat. Spinal nociception was assessed by the heat-evoked limb withdrawal in awake animals while neuronal responses were recorded in a potential brainstem relay, the rostroventromedial medulla (RVM), under pentobarbitone anesthesia. Following injection into the PVN, glutamate at...
Neuropathic pain is associated with depressive behaviour and induces neuroplast...
Gonçalves, Leonor; Silva, Rui Jorge; Ribeiro, Filipa Pinto; Pêgo, José M.; Bessa, J. M.; Pertovaara, Antti; Sousa, Nuno; Almeida, ArmandoChronic pain is associated with the development of affective disorders but the underlying mechanisms are not fully understood. Changes in brain centres implicated in both emotional and pain processing are likely to be critical in the interplay of pain control and affective emotional behaviour. In the present study, we assessed emotional behaviour and performed a structural analysis of the amygdala (AMY) in neur...
Chronic unpredictable stress inhibits nociception in male rats
Ribeiro, Filipa Pinto; Almeida, Armando; Pêgo, José M.; Cerqueira, João; Sousa, NunoChronic stress elicits remarkable alterations to the structure and function of several areas of the central nervous system. Nociception is known to be affected by chronic stress and age, although the observations are contradictory. Herein we report that both young and old rats submitted to a chronic unpredictable stress paradigm have reduced nociception in the tail-flick nociceptive test. Moreover, stressed ani...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||