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On the use of dexamethasone-loaded liposomes to induce the osteogenic different...
Monteiro, Nelson; Martins, Albino; Ribeiro, Diana Margarida da Costa; Faria, Susana, 1972-; Fonseca, Nuno A.; Moreira, João N.; Reis, R. L.Stem cells have received considerable attention by the scientific community because of their potential for tissue engineering and regenerative medicine. The most frequently used method to promote their differentiation is supplementation of the in vitro culture medium with growth/differentiation factors (GDFs). The limitations of that strategy caused by the short half-life of GDFs limit its efficacy in vivo and ...
Induction of human mesenchymal stem cells osteogenesis by bioactive agent-relea...
Monteiro, Nelson; Martins, Albino; Ribeiro, Diana Margarida da Costa; Faria, Susana, 1972-; Fonseca, Nuno A.; Moreira, João N.; Reis, R. L.Stem cell therapy is a rapidly evolving area of research in regenerative medicine. Mesenchymal stem cells (MSCs) have received considerable attention by the scientific community because of their potential of expansion and the ability to differentiate into various mesodermal tissues. Liposomes are well-established non-viral carrier systems, presenting significant advantages over other nanoparticle-based drug del...
Optimization of transient expression procedures in Catharanthus roseus and Arab...
Ribeiro, Diana Margarida da CostaDissertação de mestrado em Biotecnologia e Bio-Empreendedorismo em Plantas Aromáticas e Medicinais ; Nowadays, the availability of much gene sequence information demands the development of tools for their fast characterization at the protein level, where function actually resides. Here, the interest in the characterization of certain of the known Arabidopsis class III peroxidase (Prx) genes, as well as the int...
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