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The role and therapeutic potencial of regulators and effectors of PI3K/Akt path...

Tese de mestrado, Biologia (Biologia Molecular Humana), Universidade de Lisboa, Faculdade de Ciências, 2009 ; T-cell acute lymphoblastic leukemia (T-ALL) is a hematological cancer that mainly affects children. Although current treatments are effective, they originate significant long-term side-effects and significant number of relapses occur. Both microenvironmental and cell-autonomous cues contribute to T-ALL...