Encontrados 5 documentos, a visualizar página 1 de 1
Spatial memory impairments in a prediabetic rat model
Soares, E.; Prediger, R. D.; Nunes, S.; Castro, A. A.; Viana, S .D.; Lemos, C.; Souza, C. M. De; Agostinho, P.; Cunha, R. A.; Carvalho, E.Diabetes is associated with an increased risk for brain disorders, namely cognitive impairments associated with hippocampal dysfunction underlying diabetic encephalopathy. However, the impact of a prediabetic state on cognitive function is unknown. Therefore, we now investigated whether spatial learning and memory deficits and the underlying hippocampal dysfunction were already present in a prediabetic animal m...
Influence of the sample preparation method on the serotonin determination in pl...
Morgadinho, Maria T.; Ribeiro, C. A. Fontes; Macedo, Tice R. A.Plasma or platelet serotonin concentration is commonly used to provide information about the serotonergic activity in various psychiatric or neurological diseases. Some difficulties have been described in the measurement of serotonin (5-HT) levels in plasma or platelets. We describe an isocratic liquid-chromatographic assay with amperometric detection for determination of 5-HT in the platelet pellet and in plat...
Cyclosporin effect on noradrenaline release from the sympathetic nervous ending...
Tavares, Paula; Ribeiro, C. A. Fontes; Teixeira, F.Arterial hypertension is one of the main side effects of cyclosporin treatment and seems to be due to activation of the sympathetic nervous system. Some authors hypothesized that cyclosporin may act on the sympathetic nervous endings increasing catecholamine release, in agreement with our previous works which demonstrated an increase in rat plasma catecholamine levels after 30 mg/kg per day cyclosporin treatmen...
Efeitos Cardiovasculares da Ciclosporina num Modelo Experimental
Tavares, Paula; Reis, Flávio; Ribeiro, C. A. Fontes; Teixeira, FredericoObjectivos: Estudo dos efeitos cardiovasculares e renais da ciclosporina (CsA), num modelo animal, com doses equivalentes à Cmin e Cmax da farmacocinética humana. Métodos: Ratos Wistar machos (~300-400 g) foram tratados durante 7 semanas com CsA (Sandimmun Neoral ®) dissolvida em sumo de laranja, nas doses de 5 e 30 mg/Kg/dia. Ao grupo controlo foi administrado apenas sumo de laranja nas mesmas condições. Foi d...
The Peripheral Serotonergic System and Platelet Aggregation in Cyclosporin A-In...
Reis, Flávio; Tavares, Paula; Ribeiro, C. A. Fontes; Antunes, Ferrer; Teixeira, FredericoCyclosporin A plays an important role in preventing rejection in allograft transplant recipients. However, the therapeutic use of cyclosporin A is associated with increased incidence of thromboembolic complications and drug-related hypertension. In order to study the mechanisms by which cyclosporin A induces these abnormal pathophysiological situations, we have assessed the platelet serotonin contents and whole...
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