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Studies on enantioselective biodegradation of fluoxetine

Fluoxetine (FLX) is a chiral fluorinated pharmaceutical indicated mainly for treatment of depression and is one of the most dispensed drugs in the world. There is a clear evidence of environmental contamination with this drug. Granular sludge sequencing batch reactors (SBR) constitute a promising technology for the treatment of effluents containing micropollutants. In this study, a SBR was operated in order to...

Enantioselective Degradation of Enantiomers of Fluoxetine Followed by HPLC- FD

Environmental fate assessment of chiral pharmaceuticals is an important issue and little information is known about enantioselectivity in the environment. This kind of information is important for regulamentation of pharmaceutical industry and chiral switching processes. Fluoxetine (FLX), an anti-depressant worldwide used, is a chiral pharmaceutical prescribed in racemic form, and its main metabolite norfl...

Enantioselective Determination of Fluoxetine and Norfluoxetine in Wastewater

Microbial degradation of chiral compounds during wastewater treatment processes can be enantioselective and needs chiral analytical methodology to discriminate the biodegradation of both enantiomers. An enantioselective HPLC-FD method was developed and validated to monitor the degradation of fluoxetine (FLX) enantiomers by wastewater and the possible formation of its metabolite norfluoxetine (NFLX). The So...

Degradation of Fluoroquinolone Antibiotics and Identification of Metabolites/Tr...

Antibiotics are a therapeutic class widely found inenvironmental matrices and extensively studied due to its persistence and implications for multi-resistant bacteria development. Degradation of four fluoroquinolone antibiotics, namely Ofloxacin (OFL), Norfloxacin (NOR), Ciprofloxacin (CPF) and Moxifloxacin (MOX), at 10 mg L-1 using a mixed bacterial culture, was assessed for 60 days. The assays were follow...

Solid Phase Extraction of Fluoroquinolone Antibiotics from Wastewaters – Assess...

Microbial degradation of fluorinated pharmaceuticalsduring wastewater treatment processes remains inadequate in most situations. Due to incomplete elimination, these residues are continually being introduced into the aquatic environments in which they settle throughout time since many of them are resistant to degradation. Fluoroquinolone antibiotics due to its persistence and implication on resistant-bacteria ...

Development and Optimization of an Online SPE-HPLC-FD Method for Quantification...

Fluoroquinolones are antimicrobial agents widely found in environmental matrices and extensively studied due to their persistence and implications for multiresistant bacteria. The presence of fluoroquinolones in the environment is mainly due to the incapability of wastewater treatment plants (WWTPs) to completely remove those compounds. The amount of fluoroquinolones released through effluents depends on the ty...

Effects of fluoxetine schock loadings in a aerobic granular sludge sequencing b...

Pharmaceuticals have received increasing attention as emerging organic pollutants due to their frequent occurrence in the environment and potential adverse effects on ecossistems and to human health. Pharmaceuticals may not be completely metabolized in the human body and can enter municipal sewage systems as the parent drug and as their “biologically active” metabolites. Some of these compounds cannot be easily...

Biodegradation of chiral pharmaceuticals by an activated sludge consortium foll...

Biodegradation tends to be enantioselective in contrast to abiotic degradation and it is necessary enantioselective analytical methods to quantify the enantiomeric fraction of chiral pharmaceuticals in the environment for correct risk assessment. In this work, we developed HPLC-FD methods to follow the biodegradation of four beta-blockers: alprenolol , propranolol , metoprolol and atenolol and the antidepressan...

Enantioselective biodegradation of fluoxetine by the wild strain Labrys portuca...

Biodegradation of Beta-Blockers and Fluoxetine followed by a Chiral HPLC-FD

Despite of the massive publications concerning pharmaceuticals in the environment, the problematic related with chiral compounds and enantioselective degradation are still largely unknown [1]. Enantiomers have different interactions with enzymes, receptors and other chiral molecules, leading to different biological activities. Thus, biodegradation tends to be enantioselective in contrast to abiotic degradation....