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Timing embryo segmentation : dynamics and regulatory mechanisms of the vertebra...
Resende, Tatiana; Andrade, Raquel P.; Palmeirim, I.All vertebrate species present a segmented body, easily observed in the vertebrate column and its associated components, which provides a high degree of motility to the adult body and efficient protection of the internal organs. The sequential formation of the segmented precursors of the vertebral column during embryonic development, the somites, is governed by an oscillating genetic network, the somitogenesis ...
Temporal control of vertebrate embryo development : the role of Sonic Hedgehog ...
Resende, TatianaTese de doutoramento em Ciências da Saúde ; All vertebrate species present a segmented articulated body, which is easily observed at the vertebral column level. This segmented nature can be detected quite early during embryonic development with the periodic formation of repeated segments, the somites, along the anteriorposterior embryo body axis. These are formed as blocks of cells that bud off from the rostra...
Sonic hedgehog in temporal control of somite formation
Resende, Tatiana; Ferreira, M??nica; Teillet, Marie-Aim??e; Tavares, Ana Teresa; Andrade, Raquel P.; Palmeirim, I.Vertebrate embryo somite formation is temporally controlled by the cyclic expression of somitogenesis clock genes in the presomitic mesoderm (PSM). The somitogenesis clock is believed to be an intrinsic property of this tissue, operating independently of embryonic midline structures and the signaling molecules produced therein, namely Sonic hedgehog (Shh). This work revisits the notochord signaling contribution...
The human spindle assembly checkpoint protein Bub3 is required for the establis...
Logarinho, Elsa; Resende, Tatiana; Torres, C.; Bousbaa, HassanThe spindle assembly checkpoint monitors the status of kinetochore–microtubule (K-MT) attachments and delays anaphase onset until full metaphase alignment is achieved. Recently, the role of spindle assembly checkpoint proteins was expanded with the discovery that BubR1 and Bub1 are implicated in the regulation of K-MT attachments. One unsolved question is whether Bub3, known to form cell cycle constitutive comp...
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