Encontrados 4 documentos, a visualizar página 1 de 1

Ordenado por Data

Neurotoxic effect of oligomeric and fibrillar species of A<beta>1-42 peptide. I...

Resende, Rosa; Ferreiro, Elisabete; Pereira, Claudia; Oliveira, Catarina Resende de

http://www.sciencedirect.com/science/article/B6T0F-4SSY90W-1/1/0b10903f573d4beaec42f0dc791857e3


Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease

Resende, Rosa; Moreira, Paula Isabel; Proença, Teresa; Deshpande, Atul; Busciglio, Jorge; Pereira, Cláudia; Oliveira, Catarina Resende

Alzheimer disease (AD) is a neurodegenerative disease which is characterized by the presence of extracellular senile plaques mainly composed of amyloid-[beta] peptide (A[beta]), intracellular neurofibrillary tangles, and selective synaptic and neuronal loss. AD brains revealed elevated levels of oxidative stress markers which have been implicated in A[beta]-induced toxicity. In the present work we addressed the...


ER stress is involved in Abeta-induced GSK-3beta activation and tau phosphoryla...

Resende, Rosa; Ferreiro, Elisabete; Pereira, Cláudia; Oliveira, Catarina Resende

Intracellular neurofibrillary tangles, one of the characteristic hallmarks of Alzheimer's disease (AD), are mainly composed of hyperphosphorylated tau. The abnormal tau phosphorylation seems to be related to altered activity of kinases such as glycogen synthase kinase-3beta (GSK-3beta). Tau pathology is thought to be a later event during the progression of the disease, and it seems to occur as a consequence of ...


An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and am...

Ferreiro, Elisabete; Resende, Rosa; Costa, Rui; Oliveira, Catarina R.; Pereira, Cláudia M.F.

Prion (PrP) and amyloid-[beta] (A[beta]) peptides are involved in the neuronal loss that occurs in Prion disorders (PrD) and Alzheimer's disease (AD), respectively, partially due to Ca2+ dysregulation. Besides, the endoplasmic reticulum (ER) stress has an active role in the neurotoxic mechanisms that lead to these pathologies. Here, we analyzed whether the ER-mediated apoptotic pathway is involved in the toxic ...


4 Resultados

Texto Pesquisado

Refinar resultados

Autor











Data



Tipo de Documento


Recurso


Assunto















    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia