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Cumulative Mitoxantrone-Induced Haematological and Hepatic Adverse Effects in a...

Mitoxantrone (MTX) is an antineoplastic agent that can induce hepato- and haematotoxicity. This work aimed to investigate the occurrence of cumulative early and late MTX-induced hepatic and haematological disturbances in an vivo model. A control group and two groups treated with three cycles of 2.5 mg/kg MTX at days 0, 10 and 20 were formed. One of the treated groups suffered euthanasia on day 22 (MTX22) to eva...

Mitochondrial Cumulative Damage Induced by Mitoxantrone: Late Onset Cardiac Ene...

Mitoxantrone (MTX) is a chemotherapeutic agent, which presents late irreversible cardiotoxicity. This work aims to highlight the mechanisms involved in the MTX-induced cardiotoxicity, namely the effects toward mitochondria using in vivo and in vitro studies. Male Wistar rats were treated with 3 cycles of 2.5 mg/kg MTX at day 0, 10, and 20. One treated group was euthanized on day 22 (MTX22) to evaluate the early...

Therapeutic Concentrations of Mitoxantrone Elicit Energetic Imbalance in H9c2 C...

Mitoxantrone (MTX) is a chemotherapeutic agent that emerged as an alternative to anthracycline therapy. However, MTX also causes late cardiotoxicity, being oxidative stress and mitochondrial-impaired function proposed as possible mechanisms. This work aimed to investigate the relevance of these mechanisms to the MTX toxicity in H9c2 cells, using therapeutic concentrations. The observed cytotoxicity of MTX was t...

The metabolic profile of mitoxantrone and its relation with mitoxantrone-induce...

Mitoxantrone (MTX) is an antitumor agent that causes cardiotoxicity in 18 % patients. The metabolic profile of MTX was assessed after incubation of 100 lM MTX with hepatic S9 fraction isolated from rats. The presence of MTX and its metabolites was also assessed in vivo through the analysis of liver and heart extracts of MTX-treated rats. The cytotoxic effects of MTX and MTX metabolites were evaluated in the H9c...

Cross-Functioning between the Extraneuronal Monoamine Transporter and Multidrug...

Isolated heart cells are highly susceptible to the toxicity of catecholamine oxidation products, namely, to catecholamine-glutathione adducts. Although cellular uptake and/or efflux of these products may constitute a crucial step, the knowledge about the involvement of transporters is still very scarce. This work aimed to contribute to the characterization of membrane transport mechanisms, namely, extraneuronal...

Chemical reactivity of paraquat with the previously validated antidote, sodium ...

Reactivity of paraquat with sodium salicylate: Formation of stable complexes

Sodium salicylate (NaSAL) has been shown to be a promising antidote for the treatment of paraquat (PQ) poisonings. The modulation of the pro-oxidant and pro-inflammatory pathways, as well as the antithrombogenic properties of NaSAL are probably essential features for the healing effects provided by this drug. Nevertheless, a possible direct chemical reactivity between PQ and NaSAL is also a putative pathway to ...

Time dependent activation of transcription factors in freshly isolated cardiomy...

http://www.sciencedirect.com/science/article/B6TCR-4PKH640-H/1/d0195093d7c07e99f21ac2b29efae75f

Oxidation Process of Adrenaline in Freshly Isolated Rat Cardiomyocytes: Formati...

High concentrations of circulating biogenic catecholamines often exist during the course of several cardiovascular disorders. Additionally, coronary dysfunctions are prominent and frequently related to the ischemic and reperfusion phenomenon (I/R) in the heart, which leads to the release of large amounts of catecholamines, namely adrenaline, and to a sustained generation of reactive oxygen species (ROS). Thus, ...

Cardiotoxicidade do isoproterenol e dos produtos da sua oxidação : Estudos meca...

As catecolaminas desempenham um papel fisiológico fundamental na neurotransmissão. No entanto, quando utilizadas como agentes terapêuticos, ou, então, quando os seus níveis aumentam durante fenómenos patológicos como o feocromocitoma, a isquemia-reperfusão e o stress psicossocial, as catecolaminas podem desenvolver toxicidade ao nível cardiovascular e, mais especificamente, ao nível cardíaco. Para o estudo expe...