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Effect of scaffold architecture and BMP-2/BMP-7 delivery on in vitro bone regen...

Yilgor, Pinar; Sousa, R. A.; Reis, R. L.; Hasirci, N.; Hasirci, Vasif

The aim of this study was to develop 3-D tissue engineered constructs that mimic the in vivo conditions through a self-contained growth factor delivery system. A set of nanoparticles providing the release of BMP-2 initially followed by the release of BMP-7 were incorporated in poly(ε-caprolactone) scaffolds with different 3-D architectures produced by 3-D plotting and wet spinning. The release patterns were: ea...


Incorporation of a sequential BMP-2/BMP-7 delivery system into chitosan-based s...

Yilgor, Pinar; Tuzlakoglu, K.; Reis, R. L.; Hasirci, N.; Hasirci, Vasif

The aim of this study was to develop a 3-D construct carrying an inherent sequential growth factor delivery system. Poly(lactic acid-co-glycolic acid) (PLGA) nanocapsules loaded with bone morphogenetic protein BMP-2 and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanocapsules loaded with BMP-7 made the early release of BMP-2 and longer term release of BMP-7 possible. 3-D fiber mesh scaffolds were prepar...


3D plotted PCL scaffolds for stem cell based bone tissue engineering

Yilgor, Pinar; Sousa, R. A.; Reis, R. L.; Hasirci, N.; Hasirci, Vasif

The ability to control the architecture and strength of a bone tissue engineering scaffold is critical to achieve a harmony between the scaffold and the host tissue. Rapid prototyping (RP) technique is applied to tissue engineering to satisfy this need and to create a scaffold directly from the scanned and digitized image of the defect site. Design and construction of complex structures with different shapes an...


Biodegradable nanomats produced by electrospinning : expanding multifunctionali...

Ashammakhi, N.; Ndreu, A.; Piras, A. M.; Nikkola, L.; Sindelar, T.; Ylikauppila, H.; Harlin, A.; Gomes, Manuela E.; Neves, N. M.; Chiellini, E.

With increasing interest in nanotechnology, development of nanofibers (n-fibers) by using the technique of electrospinning is gaining new momentum. Among important potential applications of n-fiber-based structures, scaffolds for tissue-engineering represent an advancing front. Nanoscaffolds (n-scaffolds) are closer to natural extracellular matrix (ECM) and its nanoscale fibrous structure. Although the techniqu...


Solid-phase enzyme modification via affinity chromatography

Baran, E. T.; Ozer, Nazmi; Hasirci, Vasif

In the present study antileukemic enzyme L-asparaginase (ASNase) and catalase (as a model enzyme) were modified in solid-phase with activated polyethylene glycol (PEG ) by using ligand-immobilized affinity column systems L-asparagine- 2 Sepharose CL-4B and Procion red-Sepharose CL-4B, respectively. Studies on change of specific activity with modification time showed negligible differences between batches of mod...


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    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia