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Folic acid-functionalized human serum albumin nanocapsules for targeted drug de...
Rollett, Alexandra; Reiter, Tamara; Nogueira, Patrícia; Cardinale, Massimiliano; Loureiro, A.; Gomes, Andreia; Paulo, Artur Cavaco; Moreira, AlexandraActivated synovial macrophages play a key role in Rheumatoid Arthritis (RA). Recent studies have shown that folate receptor beta (FRβ) is specifically expressed by activated macrophages. Therefore a folate-based nanodevice would provide the possibility of delivering therapeutic agents to activated macrophages without affecting normal cells and tissues. This study shows for the first time the sonochemical prepa...
Data: 2012
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Origem: RepositóriUM - Universidade do Minho
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