Encontrados 4 documentos, a visualizar página 1 de 1
S4(13)-PV cell-penetrating peptide induces physical and morphological changes i...
Cardoso, Ana M. S.; Trabulo, Sara; Cardoso, Ana L.; Lorents, Annely; Morais, Catarina M.; Gomes, Paula; Nunes, Cláudia; Lúcio, Marlene; Reis, SaletteThe present work aims to gain insights into the role of peptide–lipid interactions in the mechanisms of cellular internalization and endosomal escape of the S4(13)-PV cell-penetrating peptide, which has been successfully used in our laboratory as a nucleic acid delivery system. A S4(13)-PV analogue, S4(13)-PVscr, displaying a scrambled amino acid sequence, deficient cell internalization and drug delivery inabil...
Antioxidant Versus Cytotoxic Properties of Hydroxycinnamic Acid Derivatives - A...
Esteves, Mário; Siquet, Christophe; Gaspar, Alexandra; Rio, Vitor; Sousa, Joana B.; Reis, Salette; Marques, Maria P. M.; Borges, FernandaTrihydroxycinnamic derivatives were synthesized and evaluated for their antioxidant and cytotoxic activities. The ester derivatives exhibited a higher radical-scavenging activity, when liposomes were used as target systems, a fact which may be related to their lipophilicity and conformational preferences. These compounds were found to display significant growth inhibition and cytotoxic effects towards a human c...
Automatic flow system for sequential determination of ABTS scavenging capacity ...
Magalhães, Luís M.; Segundo, Marcela A.; Reis, Salette; Lima, José L.F.C.; Tóth, Ildikó V.; Rangel, António O.S.S.In the present work, an automatic flow procedure for the sequential spectrophotometric determination of Folin-Ciocalteu reducing capacity (FC assay) and 2,2 -azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS•+) scavenging capacity expressed as the trolox equivalent (TEAC assay) is proposed for a comparative study of antioxidant properties in food products. Exploiting the flexibility of flow ...
Complexação da tetraciclina, da oxitetraciclina e da clortetraciclina com o cat...
Couto,Cristina M. C. M.; Montenegro,M. Conceição B. S. M.; Reis,SaletteStability constants of complexes formed by copper (II) with three different tetracyclines (tetracycline, oxytetracycline and chlortetracycline) have been determined potentiometrically with an automatic system in aqueous medium at 25,0 ± 0,2 ºC and I = 0,1 mol L-1 NaNO3. The protonation constants of the three tetracyclines were also determined under the same conditions. The distribution of the complexes was then...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||