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Frequency of TERT promoter mutations in human cancers

Vinagre, João; Almeida, Ana; Pópulo, Helena; Batista, Rui; Lyra, Joana; Pinto, Vasco; Coelho, Ricardo; Celestino, Ricardo; Prazeres, Hugo; Lima, Luís

Reactivation of telomerase has been implicated in human tumorigenesis, but the underlying mechanisms remain poorly understood. Here we report the presence of recurrent somatic mutations in the TERT promoter in cancers of the central nervous system (43%), bladder (59%), thyroid (follicular cell-derived, 10%) and skin (melanoma, 29%). In thyroid cancers, the presence of TERT promoter mutations (when occurring tog...

Data: 2013 | Origem: Repositório Científico do Instituto Politécnico do Porto

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Protein Kinase WNK2 has a Tumour Suppressor Role in Gliomas

Moniz, Sonia; Martinho, Olga; Pinto, Filipe; Reis, Rui Manuel; Jordan, Peter

Malignant glioblastoma is the most common and lethal adult brain tumour type. Recently, the promoter region of the protein kinaseWNK2 gene was found to be hypermethylated in 29 of 31 infiltrative gliomas and about 5 of 7 meningiomas. We have previously described that theexperimental depletion of WNK2 expression decreases RhoA activity whilst leading to increased Rac1 activity. RhoA/Rac1 activities are important...

Data: 2012 | Origem: Repositório Científico do Instituto Nacional de Saúde

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MULTINATIONAL COMPANIES OF PUBLIC WORKS IN LATIN AMERICA

Reis, Rui Manuel Gouveia Lopes dos; Universidade Lusíada, Lisboa; Reis, Henrique Manuel Pimentel; ESCE, Instituto Politécnico de Setúbal.

Public Works are a relevant activity for economicand social development. The largest companiesin this sector operate in several markets, becausedomestic markets are, usually, too small inorder to achieve interesting return levels, whichmatch with the level of investment in assets.Internationalization can use different strategiesand different foreign markets approaches.Latin America is an interesting market to s...

Data: 2010 | Origem: Tourism & Management Studies

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