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Serum total and bone alkaline phosphatase and tartrate-resistant acid phosphata...
Sousa, Cristina Maria P.; Abreu, Humberto Vaz; Viegas, Carlos A.; Azevedo, Jorge Manuel Teixeira de; Reis, Rui L.; Gomes, Manuela E.
Tissue engineered constructs based on SPCL scaffolds cultured with goat marrow ...
Rodrigues, Márcia T.; Gomes, Manuela E.; Viegas, Carlos A.; Azevedo, Jorge Manuel Teixeira de; Dias, Maria Isabel R.; Guzón, Fernando M.; Reis, Rui L.This study aims to assess the in vivo performance of cell–scaffold constructs composed of goat marrow stromal cells (GBMCs) and SPCL (a blend of starch with polycaprolactone) fibre mesh scaffolds at different stages of development, using an autologous model. GBMCs from iliac crests were seeded onto SPCL scaffolds and in vitro cultured for 1 and 7 days in osteogenic medium. After 1 and 7 days, the constructs wer...
In vivo functionality of bone tissue engineered autologous constructs obtained ...
Gomes, Manuela E.; Rodrigues, Márcia T.; Viegas, Carlos; Dias, Isabel; Azevedo, Jorge Manuel Teixeira de; Reis, Rui L.
Novel hydroxyapatite/chitosan bilayered scaffold for osteochondral tissue-engin...
Oliveira, Joaquim M.; Rodrigues, Márcia T.; Silva, Simone S.; Malafaya, Patrícia B.; Gomes, Manuela E.; Viegas, Carlos A.Recent studies suggest that bone marrow stromal cells are a potential source of osteoblasts and chondrocytes and can be used to regenerate damaged tissues using a tissue-engineering (TE) approach. However, these strategies require the use of an appropriate scaffold architecture that can support the formation de novo of either bone and cartilage tissue, or both, as in the case of osteochondral defects. The later...
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