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Characterization of monocarboxylate transporters (MCTs) expression in soft tiss...

Pinheiro, Céline; Penna, Valter; Santos, Filipa Morais; Abrahão-Machado, Lucas F.; Ribeiro, Guilherme; Curcelli, Emílio C.; Olivieri, Marcus V.

Background: Soft tissue sarcomas (STSs) are a group of neoplasms, which, despite current therapeutic advances, still confer a poor outcome to half of the patients. As other solid tumors, STSs exhibit high glucose consumption rates, associated with worse prognosis and therapeutic response. As highly glycolytic tumors, we hypothesized that sarcomas should present an increased expression of lactate transporters (M...


The prognostic role of intragenic copy number breakpoints and identification of...

Carvalho, Diana; Mackay, Alan; Bjerke, Lynn; Grundy, Richard G.; Lopes, Celeste; Reis, R. M.; Jones, Chris

BACKGROUND: Paediatric high grade glioma (pHGG) is a distinct biological entity to histologically similar tumours arising in older adults, and has differing copy number profiles and driver genetic alterations. As functionally important intragenic copy number aberrations (iCNA) and fusion genes begin to be identified in adult HGG, the same has not yet been done in the childhood setting. We applied an iCNA algori...


Monocarboxylate transporters (MCTs) in gliomas : expression and exploitation as...

Gonçalves, Vera M.; Honavar, Mrinalini; Pinheiro, Céline; Martinho, Olga; Pires, Manuel Melo; Pinheiro, Célia; Cordeiro, Michelle; Bebiano, Gil

Background. Gliomas exhibit high glycolytic rates, and monocarboxylate transporters (MCTs) play a major role in the maintenance of the glycolytic metabolism through the proton-linked transmembrane transport of lactate. However, their role in gliomas is poorly studied. Thus, we aimed to characterize the expression of MCT1, MCT4, and their chaperone CD147 and to assess the therapeutic impact of MCT inhibition in...


A hospital based cohort study of colorectal cancer cases treated at Braga Hospi...

Martins, Sandra; Reis, R. M.; Baltazar, Fátima; Longatto Filho, Adhemar

Background: Colorectal cancer (CRC) is the third most common cancer and the fourth most frequent cause of cancer death worldwide. Nonetheless, despite being a frequent cancer on which many epidemiological international studies have already been written, Portuguese epidemiological data are scarce and in particular there are very few specific data for Minho Region, which is traditionally recognized as a high inci...


Loci identified through genome-wide association studies and lung cancer risk : ...

Reis, R. M.; Mello, Ramon Andrade de; Araújo, António; Hespanhol, Venceslau

Loci identified through genome-wide association studies


RKIP Inhibition in cervical cancer Is associated with higher tumor aggressive b...

Martinho, Olga; Pinto, Filipe; Granja, Sara Costa; Gonçalves, Vera M.; Longatto Filho, Adhemar; Reis, R. M.; Loreto, Celso di; Rosner, Marsha R.

Cervical cancer is one of the most common cancers in women worldwide, being high-risk group the HPV infected, the leading etiological factor. The raf kinase inhibitory protein (RKIP) has been associated with tumor progression and metastasis in several human neoplasms, however its role on cervical cancer is unclear. In the present study, 259 uterine cervix tissues, including cervicitis, cervical intraepithelial ...


In vitro and in vivo analysis of RTK inhibitor efficacy and identification of i...

Martinho, Olga; Oliveira, Renato Silva; Gonçalves, Vera M.; Clara, Carlos; Almeida, José Reynaldo; Carvalho, André Lopes; Barata, João Taborda

Treatment for glioblastoma consists of radiotherapy and temozolomide-based chemotherapy. However, virtually all patients recur, leading to a fatal outcome. Receptor tyrosine kinase (RTK)-targeted therapy has been the focus of attention in novel treatment options for these patients. Here, we compared the efficacy of imatinib, sunitinib, and cediranib in glioblastoma models. In the present work, the biologic effe...


Absence of RKIP expression is an independent prognostic biomarker for gastric c...

Martnho, Olga; Longatto Filho, Adhemar; Reis, R. M.; Simões, Kleber; Jacob, Carlos Eduardo; Zilberstein, Bruno; Bresciani, Cláudio

Gastric cancer is a leading cause of cancer-related mortality, and the presence of lymph node metastasis an important prognostic factor. Downregulation of RKIP has been associated with tumor progression and metastasis in several types of neoplasms, being currently categorized as a metastasis suppressor gene. Our aim was to determine the expression levels of RKIP in gastric tissues and to evaluate its impact in ...


Loss of WNK2 expression by promoter gene methylation occurs in adult gliomas an...

Moniz, Sónia; Martinho, Olga; Pinto, Filipe; Sousa, Bárbara; Loureiro, Claúdia; Oliveira, Maria José; Moita, Luis Ferreira; Honavar, Mrinalini

The gene encoding protein kinase WNK2 was recently identified to be silenced by promoter hypermethylation in gliomas and meningiomas, suggesting a tumour-suppressor role in these brain tumours. Following experimental depletion in cell lines, WNK2 was further found to control GTP-loading of Rac1, a signalling guanosine triphosphatase involved in cell migration and motility. Here we show that WNK2 promoter methyl...


Histone H3.3 mutations drive pediatric glioblastoma through upregulation of MYCN

Bjerke,Lynn; Mackay, Alan; Nandhabalan, Meera; Burford, Anna; Jury, Alexa; Popov, Sergey; Bax, Dorine A.; Carvalho, Diana; Taylor, Kathryn R.

Children and young adults with glioblastoma (GBM) have a median survival rate of only 12 to 15 months, and these GBMs are clinically and biologically distinct from histologically similar cancers in older adults. They are defined by highly specific mutations in the gene encoding the histone H3.3 variant H3F3A, occurring either at or close to key residues marked by methylation for regulation of transcription-K27 ...


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    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia