Encontrados 4 documentos, a visualizar página 1 de 1
Design of polymeric nanoparticles and its applications as drug delivery systems...
Reis, C. P.; Martinho, N.; Rosado, C.; Fernandes, A. S.; Roberto, A.Objective: The aim of this study was to evaluate a formulation made of poly(lactide-co-glycolide) (PLGA) nanoparticles containing azelaic acid for potential acne treatment. Methods: Azelaic acid-loaded PLGA nanoparticles were prepared by spontaneous emulsification processes using poloxamer 188 as stabilizer. Several manufacturing parameters such as stirring rate, concentration of stabilizer and different recov...
Antimicrobial plant extracts encapsulated into polymeric beads for potential ap...
Rijo, P.; Matias, D.; Fernandes, A. S.; Simões, M. F.; Nicolai, M.; Reis, C. P.In this study, the in vitro bacterial growth inhibition, antioxidant activity and the content in bioactive components of Plectranthus barbatus, P. hadiensis var. tomentosus, P. madagascarensis, P. neochilus and P. verticillatus aqueous extracts were investigated and compared by three extraction methods (infusion, decoction and microwave extractions). The microwave extract of P. madagascariensis showed the highe...
Hydrocortisone-loaded poly(ε-caprolactone) nanoparticles for atopic dermatitis ...
Rosado, C.; Silva, C.; Reis, C. P.Atopic dermatitis (AD) is a chronic inflammatory skin condition that affects mostly young infants. The purpose of this research was to achieve a prolonged drug release and the reduction of side effects with hydrocortisone-loaded nanoparticles (NPs), for AD treatment. Poly(ε-caprolactone) (PCL) NPs were prepared by modified solvent displacement method and were characterized in terms of size, potential zeta, morp...
Development and evaluation of a novel topical treatment for acne with azelaic a...
Reis, C. P.; Gomes, A.; Rijo, P.; Candeias, S.; Pinto, P.; Baptista, M.; Martinho, N.; Ascensão, L.Azelaic acid (AzA) is used in the treatment of acne. However, side effects and low compliance have been associated with several topical treatments with AzA. Nanotechnology presents a strategy that can overcome these problems. Polymeric nanoparticles can control drug release and targeting and reduce local drug toxicity. The aim of this study was to produce and evaluate an innovative topical treatment for acne wi...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||