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Development of an HPLC method with electrochemical detection of femtomoles of 8...
Rebelo, Isabel A.; Piedade, José António P.; Oliveira-Brett, Ana MariaA selective method based on high performance liquid chromatography with electrochemical detection (HPLC-ECD) was developed to enable simultaneous detection of 8-oxo-7,8-dihydroguanine (8-oxoGua) and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo), products of DNA oxidative damage, in the presence of uric acid (UA), a strong interferent in their electrochemical detection. The method developed consists of HPLC is...
Data: 2004
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Origem: Estudo Geral - Universidade de Coimbra
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