Encontrados 2 documentos, a visualizar página 1 de 1
A new approach for determination of Na,K-ATPase activity: application to intact...
Costa, Ana R.; Real, Joana; Antunes, Célia M.; Cruz-Morais, JúlioIt has been postulated that a decrease in Na,KATPase-mediated ion gradients may be a contributing mechanism to insulin secretion. However, the precise role of the Na,K-ATPase in pancreatic β-cell membrane depolarization and insulin secretion signalling have been difficult to evaluate, mostly because data reporting changes in enzymatic activity have been obtained in cell homogenates or membrane preparations, lac...
Glucose evoked regulation of Na,K-ATPase activity in pancreatic beta-cells
Costa, A.C.R.; Real, Joana; Antunes, Célia M.; Morais, Júlio C.Glucose is the most important physiological insulin secretagogue. However, the mechanism of glucose-induced insulin release is not fully understood. The current dogma states that, in pancreatic -cell, glucose metabolism leads to an increase of ATP/ADP ratio, closure of ATP-sensitive K+ channels, membrane depolarization, opening of the voltage-dependent Ca2+ channels and Ca2+ influx which triggers insulin exocy...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||