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Inflammatory events in hippocampal slice cultures prime neuronal susceptibility...
Bernardino, Liliana; Balosso, Silvia; Ravizza, Teresa; Marchi, Nicola; Ku, George; Randle, John C.; Malva, João O.; Vezzani, AnnamariaWe investigated the consequences of transient application of specific stimuli mimicking inflammation to hippocampal tissue on microglia activation and neuronal cell vulnerability to a subsequent excitotoxic insult. Two-week-old organotypic hippocampal slice cultures, from 7-day-old C57BL/6 donor mice, were exposed for 3 h to lipopolysaccharide (LPS; 10 ng/mL) followed by 3 h co-incubation with 1 mM ATP, or 100 ...
Inactivation of Caspase-1 in Rodent Brain: A Novel Anticonvulsive Strategy
Ravizza, Teresa; Lucas, Sian-Marie; Balosso, Silvia; Bernardino, Liliana; Ku, George; Noé, Francesco; Malva, João; Randle, John C. R.; Allan, StuartPurpose: Cytokines and related inflammatory mediators are rapidly synthesized in the brain during seizures. We previously found that intracerebral administration of interleukin-1 (IL-1)-03B2 has proconvulsant effects, whereas its endogenous receptor antagonist (IL-1Ra) mediates potent anticonvulsant actions in various models of limbic seizures. In this study, we investigated whether seizures can be effectively ...
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