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Induction of cellular stress responses by phytochemicals for nutritional applic...
Lima, Cristóvão F.; Carvalho, A. C.; Gomes, A. C.; Wilson, Cristina Pereira; Rattan, S. I. S.Aging is an important risk factor for the development of age-related diseases and is associated with decreased cellular antioxidant defenses and impaired stress responses, reducing the ability of cells to cope with stress. As xenobiotics, we hypothesize that, by imposing mild stress on human cells, antioxidant phytochemicals may afford anti-aging properties through induction of stress responses and cellular ant...
Induction of cellular stress responses by phytochemicals for nutritional applic...
Lima, Cristóvão F.; Carvalho, A. C.; Gomes, A. C.; Wilson, Cristina Pereira; Rattan, S. I. S.Aging is an important risk factor for the development of age-related diseases and is associated with decreased cellular antioxidant defenses. Under the scope of the undergoing NaturAge project, our group is currently investigating the ability of some plant extracts and isolated phytochemicals to induce antioxidant defenses through Nrf2/ARE signaling. That, will be associated with possible anti-aging effects usi...
Curcumin-induced hormetic effects in human skin fibroblasts : implications towa...
Lima, Cristóvão F.; Wilson, Cristina Pereira; Rattan, S. I. S.Ageing is associated with decreased cellular antioxidant defenses and with reduced ability to induce stress responses. We have tested the curcumin-induced hormetic stimulation of cellular stress responses in normal human skin fibroblasts, and associate those with potential anti-ageing effects. Curcumin incubation for 24h induced heme oxygenase-1 (HO-1) protein levels, GST activity, GSH levels and GSH/GSSG ratio...
Induction of cellular stress responses by phytochemicals for nutritional applic...
Lima, Cristóvão F.; Carvalho, A. C.; Gomes, A. C.; Wilson, Cristina Pereira; Rattan, S. I. S.Human lifespan has increased significantly in developed and developing countries, raising considerably the percentage of elderly people. Aging is an important risk factor for the development of age-related diseases and is associated with decreased cellular antioxidant defenses and impaired stress responses, reducing the ability of cells to cope with stress. Epidemiological studies indicate a direct relationship...
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