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Lipocalin-2 is involved in emotional behaviors and cognitive function
Ferreira, Ana Catarina; Pinto, Vítor; Mesquita, Sandro; Novais, Ashley da Cruz; Sousa, João Carlos; Neves, Margarida Correia; Sousa, NunoLipocalin-2 is involved in emotional behaviors and cognitive function ; Lipocalin-2 (LCN2), an iron-related protein well described to participate in the innate immune response, has been shown to modulate spine morphology and to regulate neuronal excitability. In accordance, LCN2-null mice are reported to have stress-induced anxiety. Here we show that, under standard housing conditions, LCN2-null mice display a...
Neudesin is involved in anxiety behavior : structural and neurochemical correlates
Novais, Ashley da Cruz; Ferreira, Ana C.; Marques, Fernanda; Pêgo, José M.; Cerqueira, João; Pereira, Ana Carla David; Campos, Filipa L.Neudesin (also known as neuron derived neurotrophic factor, Nenf) is a scarcely studied putative non-canonical neurotrophic factor. In order to understand its function in the brain, we performed an extensive behavioral characterization (motor, emotional, and cognitive dimensions) of neudesin-null mice. The absence of neudesin leads to an anxious-like behavior as assessed in the elevated plus maze (EPM), light/d...
The path from the choroid plexus to the subventricular zone: go with the flow!
Falcão, Ana M.; Marques, Fernanda; Novais, Ashley da Cruz; Sousa, Nuno; Palha, Joana Almeida; Sousa, João CarlosIn adult mammals, under physiological conditions, neurogenesis, the process of generating new functional neurons from precursor cells, occurs mainly in two brain areas: the subgranular zone in the dentate gyrus of the hippocampus, and the subventricular zone (SVZ) lining the walls of the brain lateral ventricles. Taking into account the location of the SVZ and the cytoarchitecture of this periventricular neural...
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