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Mixed Protein Carriers for Modulating DNA Release
Morán, M. Carmen; Pais, Alberto A. C. C.; Ramalho, Amilcar; Miguel, M. Graça; Lindman, BjörnAqueous mixtures of oppositely charged polyelectrolytes undergo associative phase separation, resulting in coacervation, gelation, or precipitation. This phenomenon has been exploited in forming DNA gel particles by interfacial diffusion. We report here the formation of DNA gel particles by mixing solutions of double-stranded DNA with aqueous solutions containing two cationic proteins, lysozyme and protamine su...
Films based on chitosan polyelectrolyte complexes for skin drug delivery: Devel...
Silva, Cláudia L.; Pereira, Jorge C.; Ramalho, Amílcar; Pais, Alberto A. C. C.; Sousa, João J. S.Novel chitosan based polyelectrolyte complexes (PEC) were developed and optimized in order to obtain films possessing the optimal functional properties (flexibility, resistance, water vapour transmission rate and bioadhesion) to be applied on skin. The development was based on the combination of chitosan and two polyacrylic acid (PAA) polymers with different crosslinkers and crosslinking densities. The interact...
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