Encontrados 24 documentos, a visualizar página 1 de 3
Endothelial dysfunction – a major mediator of diabetic vascular disease
Sena, Cristina M.; Pereira, Ana M.; Seiça, RaquelThe vascular endothelium is a multifunctional organ and is critically involved in modulating vascular tone and structure. Endothelial cells produce a wide range of factors that also regulate cellular adhesion, thromboresistance, smooth muscle cell proliferation, and vessel wall inflammation. Thus, endothelial function is important for the homeostasis of the body and its dysfunction is associated with several pa...
Perceção dos professores e dos pais face às competências dos alunos com Síndrom...
Seiça, Raquel Alexandra Leitão deUma escola inclusiva é aquela onde todos os alunos são aceites e educados em salas regulares e recebem oportunidades adequadas às suas habilidades e necessidades. Pretende este estudo investigar e analisar a forma como os professores e os pais percecionam as competências dos alunos com síndrome de Asperger (SA) comparativamente à perceção que têm dos outros alunos sem problemas. Vários são os estudos que aponta...
Metformin promotes isolated rat liver mitochondria impairment
Carvalho, Cristina; Correia, Sónia; Santos, Maria; Seiça, Raquel; Oliveira, Catarina; Moreira, PaulaAbstract Metformin, a drug widely used in the treatment of type 2 diabetes, has recently received attention due to the new and contrasting findings regarding its effects on mitochondrial function. In the present study, we evaluated the effect of metformin in isolated rat liver mitochondria status. We observed that metformin concentrations =8 mM induce an impairment of the respiratory chain characterized by a d...
Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes
Moreira, Paula I.; Santos, Maria S.; Seiça, Raquel; Oliveira, Catarina R.It has been argued that in late-onset Alzheimer's disease a disturbance in the control of neuronal glucose metabolism consequent to impaired insulin signalling strongly resembles the pathophysiology of type 2 diabetes in non-neural tissue. The fact that mitochondria are the major generators and direct targets of reactive oxygen species led several investigators to foster the idea that oxidative stress and damag...
Estradiol affects liver mitochondrial function in ovariectomized and tamoxifen-...
Moreira, Paula I.; Custódio, José B.A.; Nunes, Elsa; Moreno, António; Seiça, Raquel; Oliveira, Catarina R.; Santos, Maria S.Given the tremendous importance of mitochondria to basic cellular functions as well as the critical role of mitochondrial impairment in a vast number of disorders, a compelling question is whether 17[beta]-estradiol (E2) modulates mitochondrial function. To answer this question we exposed isolated liver mitochondria to E2. Three groups of rat females were used: control, ovariectomized and ovariectomized treated...
Estradiol affects liver mitochondrial function in ovariectomized and tamoxifen-...
Moreira, Paula I.; Custódio, José B.A.; Nunes, Elsa; Moreno, António; Seiça, Raquel; Oliveira, Catarina R.; Santos, Maria S.Given the tremendous importance of mitochondria to basic cellular functions as well as the critical role of mitochondrial impairment in a vast number of disorders, a compelling question is whether 17[beta]-estradiol (E2) modulates mitochondrial function. To answer this question we exposed isolated liver mitochondria to E2. Three groups of rat females were used: control, ovariectomized and ovariectomized treated...
Effects of hyperglycemia on sperm and testicular cells of Goto-Kakizaki and str...
Amaral, Sandra; Moreno, António J.; Santos, Maria Sancha; Seiça, Raquel; Ramalho-Santos, JoãoDiabetes mellitus is a degenerative disease that has deleterious effects on male reproductive function, possibly through an increase in oxidative stress. This study was conducted in order to clarify the mechanisms by which oxidative stress influences animal models for both type 1 (streptozotocin-treated rats, STZ) and type 2 (Goto-Kakizaki (GK) rats) diabetes. We determined the extent of lipid peroxidation, pro...
Mitochondrial Bioenergetics, Diabetes, and Aging: Top-Down Analysis Using the D...
Ferreira, Fernanda M.; Moreno, António J.; Seiça, Raquel; Santos, Maria S.; Palmeira, Carlos M.In the present study we investigated the changes in the oxidative phosphorylation system of liver mitochondria, isolated from diabetic Goto-Kakizaki (GK) and Wistar (control) rats with different ages (6, 12, 26, and 52 weeks). We used a kinetic approach known as “top-down” analysis, which conceptually divides the oxidative phosphorylation system into two subsystems: one producing the protonmotive force (Δp) and...
Vitamin E or coenzyme Q10 administration is not fully advantageous for heart mi...
Oliveira, Paulo J.; Seica, Raquel; Santos, Dario L.; Rolo, Anabela P.; Sardao, Vilma A.; Ferreira, Fernanda M. L.; Palmeira, Carlos M.; Santos, Maria S.The heart is one of the organs affected during the later stages of diabetes. Mitochondrial function has already been proposed to be affected during the course of diabetes. Nevertheless, little information is known concerning the impact of antioxidants in heart mitochondria of a milder model for diabetes, such as the Goto-Kakizaki (GK) rat, where mitochondrial function appears ameliorated. The objective of this ...
Calcium-dependent mitochondrial permeability transition is augmented in the kid...
Oliveira, Paulo J.; Esteves, Telma C.; Seiça, Raquel; Moreno, António J. M.; Santos, Maria S.Renal disease associated with diabetes mellitus is a major problem among diabetic patients. The role of mitochondria in the pathogenesis of diabetes has received a large amount of attention in the last years, but many aspects of this subject are still poorly understood. In the present study, we studied the susceptibility of the mitochondrial permeability transition (MPT) on kidney mitochondria from the Goto-Kak...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||