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Oxidative Stress and Drugs of Abuse: An Update
Cunha-Oliveira, Teresa; Rego, A. Cristina; Oliveira, Catarina R.Drug addiction is a public health and social burden. Presently, the most abused illicit substance is cannabis, followed by amphetamines, cocaine and opioids, with different prevalence in different countries. Several evidences support a role for oxidative stress in the toxicity induced by many drugs of abuse in different organs, such as the brain, heart, liver or kidneys. This leads to oxidation of important cel...
Dysfunctional synapse in Alzheimer's disease – A focus on NMDA receptors
Mota, Sandra I.; Ferreira, Ildete L.; Rego, A. CristinaAlzheimer's disease (AD) is the most prevalent form of dementia in the elderly. Alterations capable of causing brain circuitry dysfunctions in AD may take several years to develop. Oligomeric amyloid-beta peptide (Aβ) plays a complex role in the molecular events that lead to progressive loss of function and eventually to neurodegeneration in this devastating disease. Moreover, N-methyl-d-aspartate (NMDA) recept...
Dysfunctional synapse in Alzheimer’s disease – a focus on NMDA receptors
Mota, Sandra I.; Ferreira, Ildete L.; Rego, A. CristinaAlzheimer's disease (AD) is the most prevalent form of dementia in the elderly. Alterations capable of causing brain circuitry dysfunctions in AD may take several years to develop. Oligomeric amyloid-beta peptide (Aβ) plays a complex role in the molecular events that lead to progressive loss of function and eventually to neurodegeneration in this devastating disease. Moreover, N-methyl-d-aspartate (NMDA) recept...
Cuidados de enfermagem em timpanismo
Oliveira, J.; Oliveira, J.; Rego, A.; Valente, A.; Nascimento, R.; Vala, Helena; Mesquita, J.; Nóbrega, C.O timpanismo ruminal designa-se pela acumulação excessiva de gases e por vezes fluidos no retículo-rúmen, incapazes de serem eliminados pelo organismo, o que resulta no aumento anormal do abdómen (Radostits et al, 2007). Afecta ruminantes e é uma situação que pode desenvolver-se rapidamente e pôr em risco a vida do animal (Streeter, 2009). Este estudo sintetiza a etiologia, o diagnóstico, o tratamento e aconsel...
Nursing care in gastric dilatation in dogs
Valente, A.; Rego, A.; Nascimento, R.; Oliveira, J.; Vala, Helena; Mesquita, Jr.; Nóbrega, C.Gastric Dilatation is a potentially fatal gastrointestinal pathology caused by aerophagy. It is mainly caused by rapid consumption of food, excitation or exercising near the time of feeding, which promotes the entrance of air into the stomach (Robbins et al, 2011). With this work we aim to emphasize the care given by veterinary nurses in this pathology.
Neurotoxicity of heroin-cocaine combinations in rat cortical neurons
Cunha-Oliveira, Teresa; Rego, A Cristina; Garrido, Jorge; Borges, Fernanda; Macedo, Tice; Oliveira, Catarina RCocaine and heroin are frequently co-abused by humans, in a combination known as speedball. Recently, chemical interactions between heroin (Her) or its metabolite morphine (Mor) and cocaine (Coc) were described, resulting in the formation of strong adducts. In this work, we evaluated whether combinations of Coc and Her affect the neurotoxicity of these drugs, using rat cortical neurons incubated with Coc, Her, ...
Consequences of mitochondrial dysfunction in Huntington's Disease and protectio...
Cunha-Oliveira, Teresa; Ferreira, Ildete L; Rego, A CristinaHuntington’s Disease (HD) is an autosomal dominant neurodegenerative disorder clinically characterized by psychiatric disturbances, progressive cognitive impairment and choreiform movements. These symptoms are associated with the selective atrophy and neuronal loss in the striatum, cortex and hypothalamus. The disease is caused by a mutation at the 5’ terminal of the huntingtin (HTT) gene involving the expansio...
Drugs of abuse induce apoptotic features in PC12 cells.
Oliveira, M Teresa; Rego, A Cristina; Macedo, Tice R; Oliveira, Catarina RDrugs of abuse induce the release of dopamine in the central nervous system, particularly in the mesolimbic-mesocortical pathway. As dopamine may act as a neurotoxin, in this study, we analyzed the effects of the drugs of abuse, cocaine, heroin, and amphetamine, on the neurodegeneration of PC12 cells, a dopaminergic cell line, by evaluating the activity of caspase-3 and mitochondrial cytochrome c release. All t...
Toxic Effects of Opioid and Stimulant Drugs on Undifferentiated PC12 Cells
Oliveira, M Teresa; Rego, A Cristina; Morgadinho, M Teresa; Macedo, Tice R; Oliveira, Catarina RCell death and reactive oxygen species production have been suggested to be involved in neurodegeneration induced by the drugs of abuse. In this study we analyze the toxicity of the following drugs of abuse: heroin, morphine, d-amphetamine, and cocaine in undifferentiated PC12 cells, used as dopaminergic neuronal models. Our data show that opioid drugs (heroin and morphine) are more toxic than stimulant drugs (...
Expression of NR1/NR2B N-Methyl-d-Aspartate Receptors Enhances Heroin Toxicity ...
Domingues, António; Cunha-Oliveira, Teresa; Laço, Mário LN; Macedo, Tice; Oliveira, Catarina R; Rego, A CristinaRepeated use of drugs of abuse, namely opiates, has been shown to affect glutamate-releasing neurons. Moreover, blockade of N-methyl-D-aspartate (NMDA) receptors (NMDAR) prevents cell death by apoptosis induced by morphine, a heroin metabolite. Thus, in this article we investigated the involvement of different NMDAR subunits in heroin cytotoxicity. Human embryonic kidney (HEK293)cells, which do not express nati...
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