Encontrados 8 documentos, a visualizar página 1 de 1
P2Y receptors on astrocytes and microglia mediate opposite effects in astroglia...
Quintas, C; Fraga, S; Gonçalves, J; Queiroz, GloriaNucleotides released upon brain injury signal to astrocytes and microglia playing an important role in astrogliosis, but the participation of microglia in the purinergic modulation of astrogliosis is still unclear. Highly enriched astroglial cultures and co-cultures of astrocytes and microglia were used to investigate the influence of microglia in the modulation of astroglial proliferation mediated by nucleotid...
OPPOSITE MODULATION OF ASTROGLIAL PROLIFERATION BY ADENOSINE 5 -O-(2-THIO)-DIPH...
Quintas, C.; Fraga, S.; Goncalves, J.; Queiroz, G.The contribution of P2Y(12,13) receptors to astroglial proliferation was investigated by testing the effects of two agonists with high affinity for these receptors, adenosine 5-O-(2-thio)-diphosphate (ADP beta S) and 2-methylthioadenosine-5-diphosphate (2-MeSADP), in the incorporation of [(3)H]-thymidine. The effect of ATP, an endogenous inducer of astroglial proliferation, was also investigated. ADP beta S and...
The P2Y(1) and P2Y(12) receptors mediate autoinhibition of transmitter release ...
Quintas, C; Fraga, S; Gonçalves, J; Queiroz, GIn the sympathetic nervous system, ATP is a co-transmitter and modulator of transmitter release, inhibiting noradrenaline release by acting on P2Y autoreceptors, but in peripheral tissues the subtypes involved have only scarcely been identified. We investigated the identity of the noradrenaline release-inhibiting P2Y subtypes in the epididymal portion of vas deferens and tail artery of the rat. The subtypes ope...
Congenital cystic adenomatoid malformation of the lung - the experience of five...
Rocha, G.; Fernandes, P.; Proença, E.; Quintas, C.; Martins, T.; Azevedo, I.; Guimarães, H.Background: The clinical spectrum of congenital cystic adenomatoid malformation of the lung to the neonatal intensive care units of five tertiary medical centres in the north of Portugal between 1996 and 2005. Results: Fifteen neonates with CCAML were identified, 9F/6M, birth weight 3100 g (645-3975), gestational age 38 weeks (24-40). The incidence of CCAML was 1: 9300 births. There were 11 (73%) cases of cysti...
[Chorioamnionitis and neonatal morbidity]
Rocha, G.; Proença, E.; Quintas, C.; Rodrigues, T.; Guimarães, H.CHORIOAMNIONITIS AND NEONATAL MORBIDITY Introduction - Several studies highlight the association between perinatal infection/ inflammation and neonatal morbidity, mainly bronchopulmonary dysplasia and periventricular leukomalacia. Aim – To evaluate the role of histological chorioamnionitis on the overall morbidity of preterm newborns. Methods – A retrospective study on preterm newborns less than 34 weeks gestat...
Osteomielite Aguda Neonatal - Localização Rara
Martins, C.; Guedes, R.; Miranda, N.; Pinto, R.; Quintas, C.RESUMO A osteomielite aguda é uma situação rara no período neonatal. Esta infecção óssea é mais comum nos ossos longos, como o fémur e o úmero. Quanto à etiologia, o Staphylococcus aureus é o agente mais habitualmente implicado. Clinicamente manifesta-se sob a forma aguda de sépsis ou sob a forma insidiosa. O tratamento é normalmente conservador. Os autores apresentam o caso clínico de um recém-nascido (RN), fr...
Interaction between adenosine A(2B)-receptors and alpha(2)-adrenoceptors on the...
Talaia, C; Queiroz, G; Quintas, C; Gonçalves, JIn the prostatic portion of rat vas deferens, activation of adenosine A(2B)-receptors, beta(2)-adrenoceptors, adenylyl cyclase or protein kinase A caused a facilitation of noradrenaline release. Blockade of alpha(2)-adrenoceptors with yohimbine (1 mu M) attenuated the facilitation mediated by adenosine A(2B)-receptors and by direct activation of adenylyl cyclase with forskolin but not that mediated by beta(2)-a...
Coupling to protein kinases A and C of adenosine A(2B) receptors involved in th...
Queiroz, G; Quintas, C; Talaia, C; Gonçalves, JIn the prostatic portion of rat vas deferens, the non-selective adenosine receptor agonist NECA (0.1-30 muM), but not the A(2A) agonist CGS 21680 (0.001-10 muM), caused a facilitation of electrically evoked noradrenaline release (up to 43 +/- 4%), when inhibitory adenosine A(1) receptors were blocked. NECA-elicited facilitation of noradrenaline release was prevented by the A,B receptor-antagonist MRS 1754, enha...
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